Background Stem cell therapies are finally coming of age as a viable alternative to
pancreatic islet transplantation for the treatment of insulin-dependent diabetes. Several …

Islet transplantation has now become a promising treatment for insulin-deficient diabetes
mellitus. Compared to traditional diabetes treatments, cell therapy can restore endogenous …

Objectives Readily accessible human pancreatic beta cells that are functionally close to
primary adult beta cells are a crucial model to better understand human beta cell physiology …

Generation of beta cells via transdifferentiation of other cell types is a promising avenue for
the treatment of diabetes. Here we reconstruct a single-cell atlas of the human fetal and …

Abstract Objective Type 1 Diabetes (T1D) is characterized by progressive loss of insulin-
producing pancreatic β cells as a result of autoimmune destruction. In addition to β cell …

There is a need to develop identification tests for Metabolism Disrupting Chemicals (MDCs)
with diabetogenic activity. Here we used the human EndoC-βH1 β-cell line, the rat β-cell line …

The limited availability of primary human β-cells/islets and their quality (due to donor
diversity) restrict the development of in vitro models for diabetes research. Human induced …

Type 1 diabetes is a chronic disease of the pancreas characterized by the loss of insulin-
producing beta cells. Access to human pancreas samples for research purposes has been …

Objective EndoC-βH5 is a newly established human beta-cell model which may be superior
to previous model systems. Exposure of beta cells to pro-inflammatory cytokines is widely …

Progress in diabetes research is hindered, in part, by deficiencies in current experimental
systems to accurately model human pathophysiology and/or predict clinical outcomes …