Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning

G Heusch - Circulation research, 2015 - Am Heart Assoc
Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …

Remote ischemic conditioning

G Heusch, HE Bøtker, K Przyklenk, A Redington… - Journal of the American …, 2015 - jacc.org
In remote ischemic conditioning (RIC), brief, reversible episodes of ischemia with
reperfusion in one vascular bed, tissue, or organ confer a global protective phenotype and …

[HTML][HTML] Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery

DJ Hausenloy, JA Barrabes, HE Bøtker… - Basic research in …, 2016 - Springer
To commemorate the auspicious occasion of the 30th anniversary of IPC, leading pioneers
in the field of cardioprotection gathered in Barcelona in May 2016 to review and discuss the …

The coronary circulation in acute myocardial ischaemia/reperfusion injury: a target for cardioprotection

DJ Hausenloy, W Chilian, F Crea… - Cardiovascular …, 2019 - academic.oup.com
The coronary circulation is both culprit and victim of acute myocardial infarction. The rupture
of an epicardial atherosclerotic plaque with superimposed thrombosis causes coronary …

Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite

AJ Webb, N Patel, S Loukogeorgakis, M Okorie… - …, 2008 - Am Heart Assoc
Diets rich in fruits and vegetables reduce blood pressure (BP) and the risk of adverse
cardiovascular events. However, the mechanisms of this effect have not been elucidated …

Remote ischaemic conditioning—a new paradigm of self-protection in the brain

DC Hess, RA Blauenfeldt, G Andersen… - Nature Reviews …, 2015 - nature.com
Remote ischaemic conditioning (RIC) triggers endogenous protective pathways in distant
organs such as the kidney, heart and brain, and represents an exciting new paradigm in …

Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning

P Ferdinandy, R Schulz, GF Baxter - Pharmacological reviews, 2007 - ASPET
Therapeutic strategies to protect the ischemic myocardium have been studied extensively.
Reperfusion is the definitive treatment for acute coronary syndromes, especially acute …

Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial

DJ Hausenloy, PK Mwamure, V Venugopal, J Harris… - The Lancet, 2007 - thelancet.com
Background Whether remote ischaemic preconditioning, an intervention in which brief
ischaemia of one tissue or organ protects remote organs from a sustained episode of …

Remote ischaemic preconditioning: underlying mechanisms and clinical application

DJ Hausenloy, DM Yellon - Cardiovascular research, 2008 - academic.oup.com
Remote ischaemic preconditioning (RIPC) represents a strategy for harnessing the body's
endogenous protective capabilities against the injury incurred by ischaemia and …

Cardioprotection by remote ischemic conditioning and its signal transduction

P Kleinbongard, A Skyschally, G Heusch - Pflügers Archiv-European …, 2017 - Springer
Cardioprotective strategies aim to salvage myocardium from ischemia/reperfusion injury and
to reduce infarct size and its consequences. Different stimuli, acting at sites remote from the …