For two decades, leukaemia stem cells (LSCs) in chronic myeloid leukaemia (CML) and
acute myeloid leukaemia (AML) have been advanced paradigms for the cancer stem cell …

Cancer stem cells (CSC) possess abilities generally associated with embryonic or adult
stem cells, especially self-renewal and differentiation. The CSC model assumes that this …

Stem-Cell Aging and Pathways to Precancer Evolution | New England Journal of Medicine Skip
to main content The New England Journal of Medicine homepage Advanced Search SEARCH …

The treatment of chronic myeloid leukemia (CML) with tyrosine kinase inhibitors (TKIs) has
been a model for cancer therapy development. Though most patients with CML have a …

Epithelial-to-mesenchymal transition (EMT) is associated with metastasis formation as well
as with generation and maintenance of cancer stem cells. In this way, EMT contributes to …

Chronic myeloid leukemia (CML) is caused by BCRABL1 in a cell with the biological
potential, intrinsic or acquired, to cause leukemia. This cell is commonly termed the CML …

Cancer treatment with either standard chemotherapy or targeted agents often results in the
emergence of drug-refractory cell populations, ultimately leading to therapy failure. The …

Type I interferons (IFN-1s) are antiviral cytokines that suppress blood production while
paradoxically inducing hematopoietic stem cell (HSC) proliferation. Here, we clarify the …

Significance: Blood forming, hematopoietic stem cells (HSCs) mostly reside in the bone
marrow in a quiescent, nonmotile state via adhesion interactions with stromal cells and …

Apoptosis deficiency is one of the most important features observed in neoplastic diseases.
The Bcl-2 family is composed of a subset of proteins that act as decisive apoptosis …