RAD51 recombinase plays a central role in homologous recombination (HR) by forming a
nucleoprotein filament on single-stranded DNA (ssDNA) to catalyze homology search and …

Myriad DNA-binding proteins undergo dynamic assembly, translocation, and conformational
changes while on DNA or alter the physical configuration of the DNA substrate to control its …

Templated DNA repair that occurs during homologous recombination and replication stress
relies on RAD51. RAD51 activity is positively regulated by BRCA2 and the RAD51 paralogs …

Lung cancer represents one of the most prevalent malignant neoplasms, commanding an
alarming incidence and mortality rate globally. Non-small cell lung cancer (NSCLC) …

Homologous recombination (HR) is essential for the maintenance of genome stability.
During HR, Replication Protein A (RPA) rapidly coats the 3′-tailed single-strand DNA …

Lung adenocarcinoma (LUAD) is a leading cause of cancer mortality, with many patients
facing poor prognosis, particularly those with metastatic or drug-resistant tumors …

Homologous recombination (HR) factors are crucial for DSB repair and processing stalled
replication forks. RAD51 paralogs, including RAD51B, RAD51C, RAD51D, XRCC2 and …

Fork reversal is a conserved mechanism to prevent stalled replication forks from collapsing.
Formation and protection of reversed forks are two crucial steps in ensuring fork integrity and …

Maintaining genome integrity is an essential and challenging process. RAD51 recombinase,
the central player of several crucial processes in repairing DNA and protecting genome …

RAD52 is important for the repair of DNA double-stranded breaks,, mitotic DNA synthesis,–
and alternative telomere length maintenance,. Central to these functions, RAD52 promotes …