The term matricellular proteins describes a family of structurally unrelated extracellular
macromolecules that, unlike structural matrix proteins, do not play a primary role in tissue …

Inflammation is a defensive process against tissue injury. Once this self‐protective strategy
is initiated, an effective resolution of the process is crucial to avoid major and unnecessary …

Spinal cord injury in mammals is thought to trigger scar formation with little regeneration of
axons,,–. Here we show that a crush injury to the spinal cord in neonatal mice leads to scar …

The immune response to acute muscle damage is important for normal repair. However, in
chronic diseases such as many muscular dystrophies, the immune response can amplify …

The extracellular matrix (ECM) is a complex and dynamic scaffold that maintains tissue
structure and dynamics. However, the view of the ECM as an inert architectural support has …

Thrombospondins (TSPs) are widely known as a family of five calcium-binding matricellular
proteins. While these proteins belong to the same family, they are encoded by different …

Background Pancreatic ductal adenocarcinoma (PDAC) is a stroma-rich carcinoma, and
pancreatic stellate cells (PSCs) are a major component of this dense stroma. PSCs play …

Cartilage oligomeric matrix protein (COMP) is an extracellular matrix (ECM) glycoprotein that
is critical for collagen assembly and ECM stability. Mutations of COMP cause endoplasmic …

The extracellular matrix (ECM) constituting up to 20% of the organ volume is a significant
component of the brain due to its instructive role in the compartmentalization of functional …

Endothelial cells (ECs) constitute small capillary blood vessels and contribute to delivery of
nutrients, oxygen and cellular components to the local tissues, as well as to removal of …