[HTML][HTML] N-Acetyltransferase 9 ameliorates Aβ42-mediated neurodegeneration in the Drosophila eye
P Deshpande, AV Chimata, E Snider, A Singh… - Cell Death & …, 2023 - nature.com
Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, manifests as
accumulation of amyloid-beta-42 (Aβ42) plaques and intracellular accumulation of …
accumulation of amyloid-beta-42 (Aβ42) plaques and intracellular accumulation of …
[HTML][HTML] Inactivation of Hippo and cJun-N-terminal Kinase (JNK) signaling mitigate FUS mediated neurodegeneration in vivo
Abstract Amyotrophic Lateral Sclerosis (ALS), a late-onset neurodegenerative disorder
characterized by the loss of motor neurons in the central nervous system, has no known cure …
characterized by the loss of motor neurons in the central nervous system, has no known cure …
Genetic mechanism regulating diversity in the placement of eyes on the head of animals
Despite the conservation of genetic machinery involved in eye development, there is a
strong diversity in the placement of eyes on the head of animals. Morphogen gradients of …
strong diversity in the placement of eyes on the head of animals. Morphogen gradients of …
[HTML][HTML] miR-277 targets the proapoptotic gene-hid to ameliorate Aβ42-mediated neurodegeneration in Alzheimer's model
P Deshpande, CY Chen, AV Chimata, JC Li… - Cell Death & …, 2024 - nature.com
Abstract Alzheimer's disease (AD), an age-related progressive neurodegenerative disorder,
exhibits reduced cognitive function with no cure to date. One of the reasons for AD is the …
exhibits reduced cognitive function with no cure to date. One of the reasons for AD is the …
[HTML][HTML] Physiological electric fields induce directional migration of mammalian cranial neural crest cells
During neurulation, cranial neural crest cells (CNCCs) migrate long distances from the
neural tube to their terminal site of differentiation. The pathway traveled by the CNCCs …
neural tube to their terminal site of differentiation. The pathway traveled by the CNCCs …
[HTML][HTML] Newt regeneration genes regulate Wingless signaling to restore patterning in Drosophila eye
Newts utilize their unique genes to restore missing parts by strategic regulation of conserved
signaling pathways. Lack of genetic tools poses challenges to determine the function of such …
signaling pathways. Lack of genetic tools poses challenges to determine the function of such …
Transcriptional pausing factor M1BP regulates cellular homeostasis by suppressing autophagy and apoptosis in Drosophila eye
During organogenesis cellular homeostasis plays a crucial role in patterning and growth.
The role of promoter proximal pausing of RNA polymerase II, which regulates transcription of …
The role of promoter proximal pausing of RNA polymerase II, which regulates transcription of …
[HTML][HTML] Motif 1 Binding Protein suppresses wingless to promote eye fate in Drosophila
The phenomenon of RNA polymerase II (Pol II) pausing at transcription start site (TSS) is
one of the key rate-limiting steps in regulating genome-wide gene expression. In Drosophila …
one of the key rate-limiting steps in regulating genome-wide gene expression. In Drosophila …
[HTML][HTML] Comparative transcriptomic analysis and structure prediction of novel Newt proteins
Notophthalmus viridescens (Red-spotted Newt) possess amazing capabilities to regenerate
their organs and other tissues. Previously, using a de novo assembly of the newt …
their organs and other tissues. Previously, using a de novo assembly of the newt …
Undergraduate laboratory series that employs a complete polymerase chain reaction‐restriction fragment length polymorphism experiment for determination of a …
Nowadays, novel Biochemistry lab techniques are being introduced at a very fast pace in
scientific research. This requires development of new labs for undergraduate Biochemistry …
scientific research. This requires development of new labs for undergraduate Biochemistry …