Copper is one of the most abundant basic transition metals in the human body. It takes part
in oxygen metabolism, collagen synthesis, and skin pigmentation, maintaining the integrity …

Rapid developments in Regenerative Medicine and Tissue Engineering has witnessed an
increasing drive toward clinical translation of breakthrough technologies. However, the …

Copper (Cu) is an essential micronutrient required for the activity of redox‐active enzymes
involved in critical metabolic reactions, signaling pathways, and biological functions …

Protein folding is a complex, error-prone process that often results in an irreparable protein
by-product. These by-products can be recognized by cellular quality control machineries …

Copper (Cu) is essential for living organisms, and acts as a cofactor in many metabolic
enzymes. To avoid the toxicity of free Cu, organisms have specific transport systems that …

Endosomes are dynamic intracellular compartments that control the sorting of a constant
stream of different transmembrane cargos either for ESCRT‐mediated degradation or for …

Biological copper is coordinated predominantly by just three ligand types: the side chains of
histidine, cysteine, and methionine, with of course some exceptions. The arrangement of …

The trace metal copper is essential for a variety of biological processes, but extremely toxic
when present in excessive amounts. Therefore, concentrations of this metal in the body are …

Wilson disease (WD) is an autosomal-recessive disorder of hepatocellular copper
deposition caused by pathogenic variants in the copper-transporting gene, ATP7B. Early …

The aim of this review is to give a general view on the current status of the scientific basis for
the role of copper in human health and disease, outlining the roles of copper in human …