PhysiCell: An open source physics-based cell simulator for 3-D multicellular systems
A Ghaffarizadeh, R Heiland, SH Friedman… - PLoS computational …, 2018 - journals.plos.org
Many multicellular systems problems can only be understood by studying how cells move,
grow, divide, interact, and die. Tissue-scale dynamics emerge from systems of many …
grow, divide, interact, and die. Tissue-scale dynamics emerge from systems of many …
Establishing the effects of mesoporous silica nanoparticle properties on in vivo disposition using imaging-based pharmacokinetics
The progress of nanoparticle (NP)-based drug delivery has been hindered by an inability to
establish structure-activity relationships in vivo. Here, using stable, monosized, radiolabeled …
establish structure-activity relationships in vivo. Here, using stable, monosized, radiolabeled …
Integrated PK-PD and agent-based modeling in oncology
Mathematical modeling has become a valuable tool that strives to complement conventional
biomedical research modalities in order to predict experimental outcome, generate new …
biomedical research modalities in order to predict experimental outcome, generate new …
Patient-calibrated agent-based modelling of ductal carcinoma in situ (DCIS): from microscopic measurements to macroscopic predictions of clinical progression
Ductal carcinoma in situ (DCIS)—a significant precursor to invasive breast cancer—is
typically diagnosed as microcalcifications in mammograms. However, the effective use of …
typically diagnosed as microcalcifications in mammograms. However, the effective use of …
[HTML][HTML] The role of engineering approaches in analysing cancer invasion and metastasis
MH Zaman - Nature Reviews Cancer, 2013 - nature.com
In the past decade, novel materials, probes and tools have enabled fundamental and
applied cancer researchers to take a fresh look at the complex problem of tumour invasion …
applied cancer researchers to take a fresh look at the complex problem of tumour invasion …
Transport properties of pancreatic cancer describe gemcitabine delivery and response
Background. The therapeutic resistance of pancreatic ductal adenocarcinoma (PDAC) is
partly ascribed to ineffective delivery of chemotherapy to cancer cells. We hypothesized that …
partly ascribed to ineffective delivery of chemotherapy to cancer cells. We hypothesized that …
A visually apparent and quantifiable CT imaging feature identifies biophysical subtypes of pancreatic ductal adenocarcinoma
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with
variable presentations and natural histories of disease. We hypothesized that different …
variable presentations and natural histories of disease. We hypothesized that different …
[HTML][HTML] Understanding the connection between nanoparticle uptake and cancer treatment efficacy using mathematical modeling
Nanoparticles have shown great promise in improving cancer treatment efficacy while
reducing toxicity and treatment side effects. Predicting the treatment outcome for …
reducing toxicity and treatment side effects. Predicting the treatment outcome for …
[图书][B] An introduction to physical oncology: How mechanistic mathematical modeling can improve cancer therapy outcomes
Physical oncology has the potential to revolutionize cancer research and treatment. The
fundamental rationale behind this approach is that physical processes, such as transport …
fundamental rationale behind this approach is that physical processes, such as transport …
Theory and experimental validation of a spatio-temporal model of chemotherapy transport to enhance tumor cell kill
It has been hypothesized that continuously releasing drug molecules into the tumor over an
extended period of time may significantly improve the chemotherapeutic efficacy by …
extended period of time may significantly improve the chemotherapeutic efficacy by …