Biosynthesis of pyrroloindoline-containing natural products
C Sun, W Tian, Z Lin, X Qu - Natural Product Reports, 2022 - pubs.rsc.org
Covering: up to 2022 Pyrroloindoline is a privileged tricyclic indoline motif widely present in
many biologically active and medicinally valuable natural products. Thus, understanding the …
many biologically active and medicinally valuable natural products. Thus, understanding the …
Targeted large-scale genome mining and candidate prioritization for natural product discovery
Large-scale genome-mining analyses have identified an enormous number of cryptic
biosynthetic gene clusters (BGCs) as a great source of novel bioactive natural products …
biosynthetic gene clusters (BGCs) as a great source of novel bioactive natural products …
Exploring the diverse landscape of biaryl-containing peptides generated by cytochrome P450 macrocyclases
Cytochrome P450 enzymes (P450s) catalyze diverse oxidative cross-coupling reactions
between aromatic substrates in the natural product biosynthesis. Specifically, P450s install …
between aromatic substrates in the natural product biosynthesis. Specifically, P450s install …
Unveiling an indole alkaloid diketopiperazine biosynthetic pathway that features a unique stereoisomerase and multifunctional methyltransferase
G Deletti, SD Green, C Weber, KN Patterson… - Nature …, 2023 - nature.com
Abstract The 2, 5-diketopiperazines are a prominent class of bioactive molecules. The
nocardioazines are actinomycete natural products that feature a pyrroloindoline …
nocardioazines are actinomycete natural products that feature a pyrroloindoline …
Global analysis of the biosynthetic chemical space of marine prokaryotes
Background Marine prokaryotes are a rich source of novel bioactive secondary metabolites
for drug discovery. Recent genome mining studies have revealed their great potential to bio …
for drug discovery. Recent genome mining studies have revealed their great potential to bio …
DU8ML: Machine learning-augmented density functional theory nuclear magnetic resonance computations for high-throughput in silico solution structure validation …
IM Novitskiy, AG Kutateladze - The Journal of Organic Chemistry, 2022 - ACS Publications
Machine learning (ML) profoundly improves the accuracy of the fast DU8+ hybrid density
functional theory/parametric computations of nuclear magnetic resonance spectra, allowing …
functional theory/parametric computations of nuclear magnetic resonance spectra, allowing …
Discovery, yield improvement, and application in marine coatings of potent antifouling compounds albofungins targeting multiple fouling organisms
Marine biofouling caused huge economic losses of maritime industries. We aim to develop
high-efficient, less-toxic, and cost-effective antifoulants to solve the problems of biofouling. In …
high-efficient, less-toxic, and cost-effective antifoulants to solve the problems of biofouling. In …
Chemical synthesis in competition with global genome mining and heterologous expression for the preparation of dimeric tryptophan-derived 2, 5-dioxopiperazines
P García-Domínguez, A Areal, R Alvarez… - Natural Product …, 2022 - pubs.rsc.org
Covering: up to the end of 2021 Within the 2, 5-dioxopiperazines-containing natural
products, those generated from tryptophan allow further structural diversification due to the …
products, those generated from tryptophan allow further structural diversification due to the …
A Streptomyces Cytochrome P450 Enzyme Catalyzes Regiospecific C2-Guaninylation for the Synthesis of Diverse Guanitrypmycin Analogs
Heterologous expression of a cdps-p450 locus from Streptomyces sp. NRRL S-1521 led to
the identification of guanitrypmycin D1, a new guaninylated diketopiperazine. The …
the identification of guanitrypmycin D1, a new guaninylated diketopiperazine. The …
[HTML][HTML] 基因簇大片段克隆技术研究进展及挑战
高花花， 胡娟， 刘玲丽 - 微生物学通报, 2023 - wswxtb.ijournals.cn
天然产物结构复杂, 活性多样, 是新药开发的重要来源, 对天然产物生物合成途径的研究,
有利于探索酶催化的合成机制, 促进复杂天然产物的应用. 天然产物的生物合成由其对应的基因 …
有利于探索酶催化的合成机制, 促进复杂天然产物的应用. 天然产物的生物合成由其对应的基因 …