Schistosomiasis—from immunopathology to vaccines

DP McManus, R Bergquist, P Cai… - Seminars in …, 2020 - Springer
Schistosomiasis (bilharzia) is a neglected tropical disease caused by trematode worms of
the genus Schistosoma. The transmission cycle involves human (or other mammalian) water …

Current status of vaccines for schistosomiasis

DP McManus, A Loukas - Clinical microbiology reviews, 2008 - Am Soc Microbiol
Schistosomiasis, caused by trematode blood flukes of the genus Schistosoma, is recognized
as the most important human helminth infection in terms of morbidity and mortality. Infection …

[HTML][HTML] Extracellular vesicles secreted by Schistosoma mansoni contain protein vaccine candidates

J Sotillo, M Pearson, J Potriquet, L Becker… - International journal for …, 2016 - Elsevier
Herein we show for the first time that Schistosoma mansoni adult worms secrete exosome-
like extracellular vesicles ranging from 50 to 130 nm in size. Extracellular vesicles were …

Schistosomiasis vaccines: where do we stand?

BM Tebeje, M Harvie, H You, A Loukas… - Parasites & vectors, 2016 - Springer
Schistosomiasis, caused mainly by S. mansoni, S. haematobium and S. japonicum,
continues to be a serious tropical disease and public health problem resulting in an …

Developing vaccines to combat hookworm infection and intestinal schistosomiasis

PJ Hotez, JM Bethony, DJ Diemert, M Pearson… - Nature Reviews …, 2010 - nature.com
Hookworm infection and schistosomiasis rank among the most important health problems in
developing countries. Both cause anaemia and malnutrition, and schistosomiasis also …

Schistosomiasis in the People's Republic of China: the era of the Three Gorges Dam

DP McManus, DJ Gray, Y Li, Z Feng… - Clinical microbiology …, 2010 - Am Soc Microbiol
The potential impact of the Three Gorges Dam (TGD) on schistosomiasis transmission in
China has invoked considerable global concern. The TGD will result in changes in the water …

Carcinogenic liver fluke secretes extracellular vesicles that promote cholangiocytes to adopt a tumorigenic phenotype

S Chaiyadet, J Sotillo, M Smout… - The Journal of …, 2015 - academic.oup.com
Abstract Background. Throughout Asia, there is an unprecedented link between
cholangiocarcinoma and infection with the liver fluke Opisthorchis viverrini. Multiple …

Vaccines to combat the neglected tropical diseases

JM Bethony, RN Cole, X Guo, S Kamhawi… - Immunological …, 2011 - Wiley Online Library
The neglected tropical diseases (NTDs) represent a group of parasitic and related infectious
diseases such as amebiasis, Chagas disease, cysticercosis, echinococcosis, hookworm …

[HTML][HTML] A quantitative proteomic analysis of the tegumental proteins from Schistosoma mansoni schistosomula reveals novel potential therapeutic targets

J Sotillo, M Pearson, L Becker, J Mulvenna… - International journal for …, 2015 - Elsevier
The tegument of Schistosoma mansoni plays an integral role in host–parasite interactions,
particularly during the transition from the free-living cercariae to the intra-mammalian …

Proteome analysis of the surface of Trichomonas vaginalis reveals novel proteins and strain-dependent differential expression

N de Miguel, G Lustig, O Twu, A Chattopadhyay… - Molecular & Cellular …, 2010 - ASBMB
The identification of surface proteins on the plasma membrane of pathogens is of
fundamental importance in understanding host-pathogen interactions. Surface proteins of …