[HTML][HTML] Excess body weight: Novel insights into its roles in obesity comorbidities
Excess body weight is a global health problem due to sedentary lifestyle and unhealthy diet,
affecting 2 billion population worldwide. Obesity is a major risk factor for metabolic diseases …
affecting 2 billion population worldwide. Obesity is a major risk factor for metabolic diseases …
White adipocyte dysfunction and obesity-associated pathologies in humans
CE Hagberg, KL Spalding - Nature Reviews Molecular Cell Biology, 2024 - nature.com
The prevalence of obesity and associated chronic diseases continues to increase
worldwide, negatively impacting on societies and economies. Whereas the association …
worldwide, negatively impacting on societies and economies. Whereas the association …
An integrated single cell and spatial transcriptomic map of human white adipose tissue
To date, single-cell studies of human white adipose tissue (WAT) have been based on small
cohort sizes and no cellular consensus nomenclature exists. Herein, we performed a …
cohort sizes and no cellular consensus nomenclature exists. Herein, we performed a …
DNA methylation and gene expression analysis in adipose tissue to identify new loci associated with T2D development in obesity
P Baca, F Barajas-Olmos, E Mirzaeicheshmeh… - Nutrition & …, 2022 - nature.com
Background Obesity is accompanied by excess adipose fat storage, which may lead to
adipose dysfunction, insulin resistance, and type 2 diabetes (T2D). Currently, the tendency …
adipose dysfunction, insulin resistance, and type 2 diabetes (T2D). Currently, the tendency …
Sex-specific regulation of IL-10 production in human adipose tissue in obesity
N Subramanian, B Tavira, K Hofwimmer… - Frontiers in …, 2022 - frontiersin.org
Background Obesity-associated metabolic complications display sexual dimorphism and
can be impacted by cytokines. We previously showed that interleukin-10 (IL-10) was …
can be impacted by cytokines. We previously showed that interleukin-10 (IL-10) was …
A spatiotemporal proteomic map of human adipogenesis
White adipocytes function as major energy reservoirs in humans by storing substantial
amounts of triglycerides, and their dysfunction is associated with metabolic disorders; …
amounts of triglycerides, and their dysfunction is associated with metabolic disorders; …
Emerging technologies in adipose tissue research
Technologies are transforming the understanding of adipose tissue as a complex and
dynamic tissue that plays a critical role in energy homoeostasis and metabolic health. This …
dynamic tissue that plays a critical role in energy homoeostasis and metabolic health. This …
New insights from metabolomics in pediatric renal diseases
S Riccio, MS Valentino, AP Passaro, M Izzo, S Guarino… - Children, 2022 - mdpi.com
Renal diseases in childhood form a spectrum of different conditions with potential long-term
consequences. Given that, a great effort has been made by researchers to identify candidate …
consequences. Given that, a great effort has been made by researchers to identify candidate …
CU06-1004 modulates the adenosine monophosphate (AMP)-associated protein kinase (AMPK) signaling pathway and inhibits lipogenesis in 3T3-L1 adipocytes and …
CR Bae, YG Kwon - Life Sciences, 2022 - Elsevier
Aims The endothelial dysfunction blocker CU06-1004 exhibits anti-inflammatory effects in
chronic diseases. Obesity is a major cause of chronic inflammation, and the effect of CU06 …
chronic diseases. Obesity is a major cause of chronic inflammation, and the effect of CU06 …
Adipose 'neighborhoods' collaborate to maintain metabolic health
SK Fried - Current Opinion in Genetics & Development, 2023 - Elsevier
Body fat is stored in anatomically distinct adipose depots that vary in their cell composition
and play specialized roles in systemic metabolic homeostasis via secreted products. Their …
and play specialized roles in systemic metabolic homeostasis via secreted products. Their …