Fibrinogen conversion into insoluble fibrin and the formation of a stable clot is the final step
of the coagulation cascade. Fibrin clot porosity and its susceptibility to plasmin-mediated …

The formation of fibrin clots that are relatively resistant to lysis represents the final step in
blood coagulation. We discuss the genetic and environmental regulators of fibrin structure in …

Generation of a hemostatic clot requires thrombin-mediated conversion of fibrinogen to
fibrin. Previous in vitro studies have demonstrated that the thrombin concentration present at …

Aortic aneurysm is a life-threatening disease due to the risk of aortic rupture. The only
curative treatment available relies on surgical approaches; drug-based therapies are …

Diabetes mellitus (DM) is characterized by fasting hyperglycaemia and a high risk of
atherothrombotic disorders affecting the coronary, cerebral and peripheral arterial trees. The …

Hemostatic clot formation entails thrombin-mediated cleavage of fibrinogen to fibrin.
Previous in vitro studies have shown that the thrombin concentration present during clot …

Atherothrombotic complications are the main cause of mortality in subjects with diabetes.
Premature atherosclerosis, increased platelet reactivity and activation of coagulation factors …

Diabetes (both type-1 and type-2) affects millions of individuals worldwide. A major cause of
death for individuals with diabetes is cardiovascular diseases, in part since both types of …

Objective: Post-translational modifications of fibrinogen influence the occurrence and
progression of thrombotic diseases. In this systematic review, we assessed the current …

An enhanced thrombotic environment and premature atherosclerosis are key factors for the
increased cardiovascular risk in diabetes. The occlusive vascular thrombus, formed …