Fibrin clot properties in cardiovascular disease: from basic mechanisms to clinical practice
M Ząbczyk, RAS Ariëns, A Undas - Cardiovascular research, 2023 - academic.oup.com
Fibrinogen conversion into insoluble fibrin and the formation of a stable clot is the final step
of the coagulation cascade. Fibrin clot porosity and its susceptibility to plasmin-mediated …
of the coagulation cascade. Fibrin clot porosity and its susceptibility to plasmin-mediated …
Fibrin clot structure and function: a role in the pathophysiology of arterial and venous thromboembolic diseases
A Undas, RAS Ariëns - Arteriosclerosis, thrombosis, and vascular …, 2011 - Am Heart Assoc
The formation of fibrin clots that are relatively resistant to lysis represents the final step in
blood coagulation. We discuss the genetic and environmental regulators of fibrin structure in …
blood coagulation. We discuss the genetic and environmental regulators of fibrin structure in …
Thrombin generation and fibrin clot structure
AS Wolberg - Blood reviews, 2007 - Elsevier
Generation of a hemostatic clot requires thrombin-mediated conversion of fibrinogen to
fibrin. Previous in vitro studies have demonstrated that the thrombin concentration present at …
fibrin. Previous in vitro studies have demonstrated that the thrombin concentration present at …
Diabetes and aortic aneurysm: current state of the art
Aortic aneurysm is a life-threatening disease due to the risk of aortic rupture. The only
curative treatment available relies on surgical approaches; drug-based therapies are …
curative treatment available relies on surgical approaches; drug-based therapies are …
Diabetes mellitus as a prothrombotic condition
PJ Grant - Journal of internal medicine, 2007 - Wiley Online Library
Diabetes mellitus (DM) is characterized by fasting hyperglycaemia and a high risk of
atherothrombotic disorders affecting the coronary, cerebral and peripheral arterial trees. The …
atherothrombotic disorders affecting the coronary, cerebral and peripheral arterial trees. The …
Thrombin generation, fibrin clot formation and hemostasis
AS Wolberg, RA Campbell - Transfusion and Apheresis Science, 2008 - Elsevier
Hemostatic clot formation entails thrombin-mediated cleavage of fibrinogen to fibrin.
Previous in vitro studies have shown that the thrombin concentration present during clot …
Previous in vitro studies have shown that the thrombin concentration present during clot …
Coagulation and fibrinolysis in diabetes
SH Alzahrani, RA Ajjan - Diabetes and Vascular Disease …, 2010 - journals.sagepub.com
Atherothrombotic complications are the main cause of mortality in subjects with diabetes.
Premature atherosclerosis, increased platelet reactivity and activation of coagulation factors …
Premature atherosclerosis, increased platelet reactivity and activation of coagulation factors …
[HTML][HTML] Coagulatory defects in type-1 and type-2 diabetes
AIS Sobczak, AJ Stewart - International journal of molecular sciences, 2019 - mdpi.com
Diabetes (both type-1 and type-2) affects millions of individuals worldwide. A major cause of
death for individuals with diabetes is cardiovascular diseases, in part since both types of …
death for individuals with diabetes is cardiovascular diseases, in part since both types of …
Effects of post-translational modifications of fibrinogen on clot formation, clot structure, and fibrinolysis: a systematic review
JJ de Vries, CJM Snoek, DC Rijken… - … , and vascular biology, 2020 - Am Heart Assoc
Objective: Post-translational modifications of fibrinogen influence the occurrence and
progression of thrombotic diseases. In this systematic review, we assessed the current …
progression of thrombotic diseases. In this systematic review, we assessed the current …
[HTML][HTML] Hypofibrinolysis in diabetes: a therapeutic target for the reduction of cardiovascular risk
An enhanced thrombotic environment and premature atherosclerosis are key factors for the
increased cardiovascular risk in diabetes. The occlusive vascular thrombus, formed …
increased cardiovascular risk in diabetes. The occlusive vascular thrombus, formed …