Proteolysis of structural molecules of the extracellular matrix (ECM) is an irreversible post-
translational modification in all arthropathies. Common joint disorders, including …

The extracellular matrix (ECM) consists of numerous macromolecules classified traditionally
into collagens, elastin, and microfibrillar proteins, proteoglycans including hyaluronan, and …

Human cartilage is a complex tissue of matrix proteins that vary in amount and orientation
from superficial to deep layers and from loaded to unloaded zones. A major challenge to …

Articular cartilage shows limited self-healing ability owing to its low cellularity and
avascularity. Untreated cartilage defects display an increased propensity to degenerate …

It has been suggested that increased collagenase-3 (MMP-13) activity plays a pivotal role in
the pathogenesis of osteoarthritis (OA). We have used tetracycline-regulated transcription in …

OBJECTIVE: Osteoarthritis (OA) is a chronic and slowly progressive disease for which
biomarkers may be able to provide a more rapid indication of therapeutic responses to …

The poor regenerative capacity of articular cartilage presents a major clinical challenge and
may relate to a limited turnover of the cartilage collagen matrix. However, the collagen …

Objective To profile the expression of all known members of the matrix metalloproteinase
(MMP), ADAMTS, and tissue inhibitor of metalloproteinases (TIMP) gene families in normal …

(OA) as well as in rheumatoid arthritis (RA) and other inflammation arthritides. It leads to a
loss of joint function, frequently accompanied by debilitating pain. In idiopathic OA this is a …

Osteoarthritis (OA) is the most common form of arthritic disease, and a major cause of
disability and impaired quality of life in the elderly. OA is a complex disease of the entire …