Matrix metalloproteinases in arthritis: towards precision medicine
B Grillet, RVS Pereira, J Van Damme… - Nature Reviews …, 2023 - nature.com
Proteolysis of structural molecules of the extracellular matrix (ECM) is an irreversible post-
translational modification in all arthropathies. Common joint disorders, including …
translational modification in all arthropathies. Common joint disorders, including …
Extracellular matrix molecules: potential targets in pharmacotherapy
H Järveläinen, A Sainio, M Koulu, TN Wight… - Pharmacological …, 2009 - ASPET
The extracellular matrix (ECM) consists of numerous macromolecules classified traditionally
into collagens, elastin, and microfibrillar proteins, proteoglycans including hyaluronan, and …
into collagens, elastin, and microfibrillar proteins, proteoglycans including hyaluronan, and …
[HTML][HTML] Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis
MB Goldring, M Otero, DA Plumb… - European cells & …, 2011 - ncbi.nlm.nih.gov
Human cartilage is a complex tissue of matrix proteins that vary in amount and orientation
from superficial to deep layers and from loaded to unloaded zones. A major challenge to …
from superficial to deep layers and from loaded to unloaded zones. A major challenge to …
Chondrocyte hypertrophy in osteoarthritis: mechanistic studies and models for the identification of new therapeutic strategies
Articular cartilage shows limited self-healing ability owing to its low cellularity and
avascularity. Untreated cartilage defects display an increased propensity to degenerate …
avascularity. Untreated cartilage defects display an increased propensity to degenerate …
Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice
LA Neuhold, L Killar, W Zhao… - The Journal of …, 2001 - Am Soc Clin Investig
It has been suggested that increased collagenase-3 (MMP-13) activity plays a pivotal role in
the pathogenesis of osteoarthritis (OA). We have used tetracycline-regulated transcription in …
the pathogenesis of osteoarthritis (OA). We have used tetracycline-regulated transcription in …
[HTML][HTML] Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis
VB Kraus, B Burnett, J Coindreau, S Cottrell… - Osteoarthritis and …, 2011 - Elsevier
OBJECTIVE: Osteoarthritis (OA) is a chronic and slowly progressive disease for which
biomarkers may be able to provide a more rapid indication of therapeutic responses to …
biomarkers may be able to provide a more rapid indication of therapeutic responses to …
Radiocarbon dating reveals minimal collagen turnover in both healthy and osteoarthritic human cartilage
KM Heinemeier, P Schjerling, J Heinemeier… - Science translational …, 2016 - science.org
The poor regenerative capacity of articular cartilage presents a major clinical challenge and
may relate to a limited turnover of the cartilage collagen matrix. However, the collagen …
may relate to a limited turnover of the cartilage collagen matrix. However, the collagen …
Expression profiling of metalloproteinases and their inhibitors in cartilage
L Kevorkian, DA Young, C Darrah… - … : Official Journal of …, 2004 - Wiley Online Library
Objective To profile the expression of all known members of the matrix metalloproteinase
(MMP), ADAMTS, and tissue inhibitor of metalloproteinases (TIMP) gene families in normal …
(MMP), ADAMTS, and tissue inhibitor of metalloproteinases (TIMP) gene families in normal …
Type II collagen degradation and its regulation in articular cartilage in osteoarthritis
AR Poole, M Kobayashi, T Yasuda, S Laverty… - Annals of the …, 2002 - ard.bmj.com
(OA) as well as in rheumatoid arthritis (RA) and other inflammation arthritides. It leads to a
loss of joint function, frequently accompanied by debilitating pain. In idiopathic OA this is a …
loss of joint function, frequently accompanied by debilitating pain. In idiopathic OA this is a …
The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?
Osteoarthritis (OA) is the most common form of arthritic disease, and a major cause of
disability and impaired quality of life in the elderly. OA is a complex disease of the entire …
disability and impaired quality of life in the elderly. OA is a complex disease of the entire …