Noninvasive methods to modulate G protein-coupled receptors (GPCRs) with temporal and
spatial precision are in great demand. Photopharmacology uses photons to control in situ …

This review article provides an overview of the structure, location, and functional uses of H3
and H4 histamine receptors. It examines the current research on the topic, including the …

Key points Melanin‐concentrating hormone (MCH) neurons express histamine‐3 receptor
(H3R) mRNA but not histamine‐1 (H1R) or histamine‐2 (H2R) receptor mRNA. Histamine …

The striatum is innervated by histaminergic fibers and expresses a high density of histamine
H 3 receptors (H 3 Rs), present on medium spiny neurons (MSNs) and corticostriatal …

Agonist potency at some neurotransmitter receptors has been shown to be regulated by
voltage, a mechanism which has been suggested to play a crucial role in the regulation of …

The dopamine D2 receptor plays a critical role in activity‐dependent synaptic plasticity in the
striatum, and regulates the transitions between different states of electrical activity. The D2 …

Adenosine A2A receptors (A2ARs) and dopamine D2 receptors (D2Rs) form constitutive
heteromers in living cells and exhibit a strong functional antagonistic interaction. Recent …

Bioluminescence and fluorescence resonance energy transfer (BRET and FRET) together
with the proximity ligation method revealed the existence of G-protein-coupled receptors …

Ion Channel-Coupled Receptors (ICCRs) are artificial receptor-channel fusion proteins
designed to couple ligand binding to channel gating. We previously validated the ICCR …

Histamine mediates a multitude of physiological effects in the human body by activating four
histamine receptor subtypes. Histamine receptors have proven to be promising drug targets …