Gene-environment interaction and psychiatric disorders: Review and future directions

E Assary, JP Vincent, R Keers, M Pluess - Seminars in cell & …, 2018 - Elsevier
Empirical studies suggest that psychiatric disorders result from a complex interplay between
genetic and environmental factors. Most evidence for such gene-environment interaction …

Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits

A Caspi, AR Hariri, A Holmes, R Uher… - American journal of …, 2010 - Am Psychiatric Assoc
Evidence of marked variability in response among people exposed to the same
environmental risk implies that individual differences in genetic susceptibility might be at …

Use caution when applying behavioural science to policy

H IJzerman, NA Lewis Jr, AK Przybylski… - Nature Human …, 2020 - nature.com
Social and behavioural scientists have attempted to speak to the COVID-19 crisis. But is
behavioural research on COVID-19 suitable for making policy decisions? We offer a …

A direct test of the diathesis–stress model for depression

L Colodro-Conde, B Couvy-Duchesne, G Zhu… - Molecular …, 2018 - nature.com
The diathesis–stress theory for depression states that the effects of stress on the depression
risk are dependent on the diathesis or vulnerability, implying multiplicative interactive effects …

The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation

K Karg, M Burmeister, K Shedden… - Archives of general …, 2011 - jamanetwork.com
Objective: To perform a meta-analysis including all relevant studies exploring the interaction.
Data Sources: We identified studies published through November 2009 in PubMed. Study …

Epigenetics and the biological definition of gene× environment interactions

MJ Meaney - Child development, 2010 - Wiley Online Library
Variations in phenotype reflect the influence of environmental conditions during
development on cellular functions, including that of the genome. The recent integration of …

Psychobiology and molecular genetics of resilience

A Feder, EJ Nestler, DS Charney - Nature Reviews Neuroscience, 2009 - nature.com
Every individual experiences stressful life events. In some cases acute or chronic stress
leads to depression and other psychiatric disorders, but most people are resilient to such …

The evolution of the cognitive model of depression and its neurobiological correlates

AT Beck - American journal of psychiatry, 2008 - Am Psychiatric Assoc
Although the cognitive model of depression has evolved appreciably since its first
formulation over 40 years ago, the potential interaction of genetic, neurochemical, and …

Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis

N Risch, R Herrell, T Lehner, KY Liang, L Eaves, J Hoh… - Jama, 2009 - jamanetwork.com
Context Substantial resources are being devoted to identify candidate genes for complex
mental and behavioral disorders through inclusion of environmental exposures following the …

[图书][B] Behavioral genetics

R Plomin - 2008 - books.google.com
Behavioral Genetics, Fifth Edition provides an engaging and clear overview of human and
animal behavioral genetics that is designed to introduce students in the behavioral …