Tumorigenesis is a complex and dynamic process, consisting of three stages: initiation,
progression, and metastasis. Tumors are encircled by extracellular matrix (ECM) and …

The vasa vasorum are a vital microvascular network supporting the outer wall of larger blood
vessels. Although these dynamic microvessels have been studied for centuries, the …

Progress has been made in elucidating the cell-surface phenotype of primary adipose
progenitors; however, specific functional markers and distinct molecular signatures of fat …

Pericytes are mural cells of the microcirculation that have been shown to play key roles in
regulating microvascular morphogenesis and stability throughout each tissue bed and organ …

Many features of adipose tissue-specific stem/progenitor cells, such as physiological
function and localization, have recently been examined. Adipose-tissue turnover is very slow …

Adipose tissue-derived stem cells (ADSC) are routinely isolated from the stromal vascular
fraction (SVF) of homogenized adipose tissue. Similar to other types of mesenchymal stem …

Subcutaneous fat has emerged as an alternative tissue source for stromal/stem cells in
regenerative medicine. Over the past decade, international research efforts have …

Current treatment modalities for soft tissue defects caused by various pathologies and
trauma include autologous grafting and commercially available fillers. However, these …

A major challenge in tissue engineering is the generation of sufficient volumes of viable
tissue for organ transplant. The development of a stable, mature vasculature is required to …

MSC have been used in diverse animal disease models to investigate their regenerative
capacity. Although the clinical outcome was often encouraging, the mode of action of the …