[HTML][HTML] The world of protein acetylation
Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
[HTML][HTML] Spotlight on protein N-terminal acetylation
N-terminal acetylation (Nt-acetylation) is a widespread protein modification among
eukaryotes and prokaryotes alike. By appending an acetyl group to the N-terminal amino …
eukaryotes and prokaryotes alike. By appending an acetyl group to the N-terminal amino …
[HTML][HTML] Co-translational, post-translational, and non-catalytic roles of N-terminal acetyltransferases
Recent studies of N-terminal acetylation have identified new N-terminal acetyltransferases
(NATs) and expanded the known functions of these enzymes beyond their roles as ribosome …
(NATs) and expanded the known functions of these enzymes beyond their roles as ribosome …
[HTML][HTML] First things first: vital protein marks by N-terminal acetyltransferases
N-terminal (Nt) acetylation is known to be a highly abundant co-translational protein
modification, but the recent discovery of Golgi-and chloroplast-resident N-terminal …
modification, but the recent discovery of Golgi-and chloroplast-resident N-terminal …
Proteome complexity and the forces that drive proteome imbalance
JW Harper, EJ Bennett - Nature, 2016 - nature.com
The cellular proteome is a complex microcosm of structural and regulatory networks that
requires continuous surveillance and modification to meet the dynamic needs of the cell. It is …
requires continuous surveillance and modification to meet the dynamic needs of the cell. It is …
[HTML][HTML] Post-translational modifications of the protein termini
Post-translational modifications (PTM) involve enzyme-mediated covalent addition of
functional groups to proteins during or after synthesis. These modifications greatly increase …
functional groups to proteins during or after synthesis. These modifications greatly increase …
A genomic history of Aboriginal Australia
The population history of Aboriginal Australians remains largely uncharacterized. Here we
generate high-coverage genomes for 83 Aboriginal Australians (speakers of Pama …
generate high-coverage genomes for 83 Aboriginal Australians (speakers of Pama …
Protein N-terminal acetyltransferases: when the start matters
The majority of eukaryotic proteins are subjected to N-terminal acetylation (Nt-acetylation),
catalysed by N-terminal acetyltransferases (NATs). Recently, the structure of an NAT …
catalysed by N-terminal acetyltransferases (NATs). Recently, the structure of an NAT …
N‐terminal modifications of cellular proteins: the enzymes involved, their substrate specificities and biological effects
The vast majority of eukaryotic proteins are N‐terminally modified by one or more
processing enzymes. Enzymes acting on the very first amino acid of a polypeptide include …
processing enzymes. Enzymes acting on the very first amino acid of a polypeptide include …
N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex
Although many eukaryotic proteins are amino (N)–terminally acetylated, structural
mechanisms by which N-terminal acetylation mediates protein interactions are largely …
mechanisms by which N-terminal acetylation mediates protein interactions are largely …