Context-specific regulation of extracellular vesicle biogenesis and cargo selection

AC Dixson, TR Dawson, D Di Vizio… - … Reviews Molecular Cell …, 2023 - nature.com
To coordinate, adapt and respond to biological signals, cells convey specific messages to
other cells. An important aspect of cell–cell communication involves secretion of molecules …

Extracellular vesicles and nanoparticles: emerging complexities

DK Jeppesen, Q Zhang, JL Franklin, RJ Coffey - Trends in Cell Biology, 2023 - cell.com
The study of extracellular vesicles (EVs) and nanoparticles (NPs) is rapidly expanding
because recent discoveries have revealed a much greater complexity and diversity than was …

The role of extracellular vesicles in cancer

R Kalluri, KM McAndrews - Cell, 2023 - cell.com
Intercellular communication is a key feature of cancer progression and metastasis.
Extracellular vesicles (EVs) are generated by all cells, including cancer cells, and recent …

[HTML][HTML] Autophagy in inflammation, infection, and immunometabolism

V Deretic - Immunity, 2021 - cell.com
Autophagy is a quality-control, metabolic, and innate immunity process. Normative
autophagy affects many cell types, including hematopoietic as well as non-hematopoietic …

β-Coronaviruses use lysosomes for egress instead of the biosynthetic secretory pathway

S Ghosh, TA Dellibovi-Ragheb, A Kerviel, E Pak, Q Qiu… - Cell, 2020 - cell.com
Summary β-Coronaviruses are a family of positive-strand enveloped RNA viruses that
includes the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Much is …

Persistent coxsackievirus B infection and pathogenesis of type 1 diabetes mellitus

MP Nekoua, EK Alidjinou, D Hober - Nature Reviews Endocrinology, 2022 - nature.com
Enteroviruses are believed to trigger or accelerate islet autoimmunity in genetically
susceptible individuals, thereby resulting in loss of functional insulin-producing β-cells and …

[HTML][HTML] Autophagy during viral infection—a double-edged sword

Y Choi, JW Bowman, JU Jung - Nature Reviews Microbiology, 2018 - nature.com
Autophagy is a powerful tool that host cells use to defend against viral infection. Double-
membrane vesicles, termed autophagosomes, deliver trapped viral cargo to the lysosome …

Lysosomal exocytosis, exosome release and secretory autophagy: the autophagic-and endo-lysosomal systems go extracellular

S Buratta, B Tancini, K Sagini, F Delo… - International journal of …, 2020 - mdpi.com
Beyond the consolidated role in degrading and recycling cellular waste, the autophagic-and
endo-lysosomal systems play a crucial role in extracellular release pathways. Lysosomal …

Double-membrane vesicles as platforms for viral replication

G Wolff, CE Melia, EJ Snijder, M Bárcena - Trends in microbiology, 2020 - cell.com
Viruses, as obligate intracellular parasites, exploit cellular pathways and resources in a
variety of fascinating ways. A striking example of this is the remodelling of intracellular …

Extracellular membrane vesicles in the three domains of life and beyond

S Gill, R Catchpole, P Forterre - FEMS microbiology reviews, 2019 - academic.oup.com
Cells from all three domains of life, Archaea, Bacteria and Eukarya, produce extracellular
vesicles (EVs) which are sometimes associated with filamentous structures known as …