Oligodendrocytes generate multiple layers of myelin membrane around axons of the central
nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve …

Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies (MOG-Abs) were first detected
by immunoblot and enzyme-linked immunosorbent assay nearly 30 years ago, but their …

Neuromyelitis optica spectrum disorder (NMOSD) is an uncommon inflammatory disease of
the central nervous system, manifesting clinically as optic neuritis, myelitis, and certain brain …

Over the past few years, new-generation cell-based assays have demonstrated a robust
association of autoantibodies to full-length human myelin oligodendrocyte glycoprotein …

Abstract See de Seze (doi: 10.1093/brain/awx292) for a scientific commentary on this article.
A condition associated with an autoantibody against MOG has been recently recognized as …

The diagnosis of multiple sclerosis is based on neurological symptoms and signs, alongside
evidence of dissemination of CNS lesions in space and time. MRI is often sufficient to …

Neuromyelitis optica (NMO) is an inflammatory CNS syndrome distinct from multiple
sclerosis (MS) that is associated with serum aquaporin-4 immunoglobulin G antibodies …

B cells are essential components of the adaptive immune system and have important roles
in the pathogenesis of several central nervous system (CNS) diseases. Besides producing …

Background A subset of patients with neuromyelitis optica spectrum disorders (NMOSD) has
been shown to be seropositive for myelin oligodendrocyte glycoprotein antibodies (MOG …

Conformation-sensitive antibodies against myelin oligodendrocyte glycoprotein (MOG) are
detectable in patients with optic neuritis, myelitis, opticomyelitis, acute or multiphasic …