Liposomal nanocarriers for plasminogen activators

S Koudelka, R Mikulik, J Mašek, M Raška… - Journal of controlled …, 2016 - Elsevier
Several plasminogen activators (PAs) have been found effective in treating different
thromboembolic diseases. However, administration of conventional thrombolytic therapy is …

Platelet microparticle-inspired clot-responsive nanomedicine for targeted fibrinolysis

CL Pawlowski, W Li, M Sun, K Ravichandran… - Biomaterials, 2017 - Elsevier
Intravascular administration of plasminogen activators is a clinically important thrombolytic
strategy to treat occlusive vascular conditions. A major issue with this strategy is the systemic …

Functionalized carriers for the improved delivery of plasminogen activators

B Vaidya, GP Agrawal, SP Vyas - International journal of pharmaceutics, 2012 - Elsevier
Various plasminogen activators have been routinely used for the treatment of thrombotic
diseases. However, these agents possess various problems eg short half life and other …

[图书][B] Handbook of clinical nanomedicine: nanoparticles, imaging, therapy, and clinical applications

R Bawa, GF Audette, I Rubinstein - 2016 - books.google.com
This handbook (55 chapters) provides a comprehensive roadmap of basic research in
nanomedicine as well as clinical applications. However, unlike other texts in nanomedicine …

Cytotoxicity of chitosan/streptokinase nanoparticles as a function of size: an artificial neural networks study

H Baharifar, A Amani - Nanomedicine: Nanotechnology, Biology and …, 2016 - Elsevier
Predicting the size and toxicity of chitosan/streptokinase nanoparticles at various values of
processing parameters was the aim of this study. For the first time, a comprehensive model …

Preparation of thermosensitive magnetic liposome encapsulated recombinant tissue plasminogen activator for targeted thrombolysis

HL Hsu, JP Chen - Journal of Magnetism and Magnetic Materials, 2017 - Elsevier
Recombinant tissue plasminogen activator (rtPA) was encapsulated in thermosensitive
magnetic liposome (TML) prepared from 1, 2-dipalmitoyl-sn-glycero-3-phosphocholine …

Optimization of self-assembled chitosan/streptokinase nanoparticles and evaluation of their cytotoxicity and thrombolytic activity

H Baharifar, G Tavoosidana, R Karimi… - … of nanoscience and …, 2015 - ingentaconnect.com
In this study, the enzyme streptokinase (thrombolysis agent) and chitosan (Cs) nanoparticles
were prepared by self-assembly. Using experimental design, chitosan concentration …

Nanoscience and nanoengineering: advances and applications

AD Kelkar, DJC Herr, JG Ryan - 2014 - books.google.com
Reflecting the breadth of the field from research to manufacturing, Nanoscience and
Nanoengineering: Advances and Applications delivers an in-depth survey of emerging, high …

Translational initiatives in thrombolytic therapy

ME Klegerman - Frontiers of medicine, 2017 - Springer
Once thrombi have formed as part of the pathology defining myocardial infarction, ischemic
stroke, peripheral arterial disease, deep venous thrombosis or other embolic disorders, the …

Micro and Nanoparticles as Carriers for Streptokinase: A Mini-Review on Efficacy, Side Effects and Pharmacokinetics

A Amani - Nanomedicine Research Journal, 2024 - nanomedicine-rj.com
Streptokinase is being successfully used as a thrombolytic agent for restoring the blood flow
following thromboembolism and myocardial infarction. However, high immunogenicity of the …