New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?
K Luger, ML Dechassa, DJ Tremethick - Nature reviews Molecular cell …, 2012 - nature.com
The compaction of genomic DNA into chromatin has profound implications for the regulation
of key processes such as transcription, replication and DNA repair. Nucleosomes, the …
of key processes such as transcription, replication and DNA repair. Nucleosomes, the …
[HTML][HTML] Histones: at the crossroads of peptide and protein chemistry
MM Müller, TW Muir - Chemical reviews, 2015 - ACS Publications
1. INTRODUCTION In eukaryotic cells, inheritable information is stored in a nucleoprotein
complex referred to as chromatin. 1 This genome architecture serves two key purposes. On …
complex referred to as chromatin. 1 This genome architecture serves two key purposes. On …
Structural basis of histone H2A–H2B recognition by the essential chaperone FACT
Facilitates chromatin transcription (FACT) is a conserved histone chaperone that
reorganizes nucleosomes and ensures chromatin integrity during DNA transcription …
reorganizes nucleosomes and ensures chromatin integrity during DNA transcription …
Single-molecule analysis and engineering of DNA motors
Molecular motors are diverse enzymes that transduce chemical energy into mechanical
work and, in doing so, perform critical cellular functions such as DNA replication and …
work and, in doing so, perform critical cellular functions such as DNA replication and …
Overcoming the nucleosome barrier during transcript elongation
SJ Petesch, JT Lis - Trends in genetics, 2012 - cell.com
RNA polymerase II (Pol II) must break the nucleosomal barrier to gain access to DNA and
transcribe genes efficiently. New single-molecule techniques have elucidated many …
transcribe genes efficiently. New single-molecule techniques have elucidated many …
[HTML][HTML] H2A. Z controls the stability and mobility of nucleosomes to regulate expression of the LH genes
S Rudnizky, A Bavly, O Malik, L Pnueli… - Nature …, 2016 - nature.com
The structure and dynamics of promoter chromatin have a profound effect on the expression
levels of genes. Yet, the contribution of DNA sequence, histone post-translational …
levels of genes. Yet, the contribution of DNA sequence, histone post-translational …
Real-time multistep asymmetrical disassembly of nucleosomes and chromatosomes visualized by high-speed atomic force microscopy
B Onoa, C Díaz-Celis, C Cañari-Chumpitaz… - ACS Central …, 2023 - ACS Publications
During replication, expression, and repair of the eukaryotic genome, cellular machinery must
access the DNA wrapped around histone proteins forming nucleosomes. These octameric …
access the DNA wrapped around histone proteins forming nucleosomes. These octameric …
Histone H4 tail mediates allosteric regulation of nucleosome remodelling by linker DNA
Imitation switch (ISWI)-family remodelling enzymes regulate access to genomic DNA by
mobilizing nucleosomes. These ATP-dependent chromatin remodellers promote …
mobilizing nucleosomes. These ATP-dependent chromatin remodellers promote …
Gold rotor bead tracking for high-speed measurements of DNA twist, torque and extension
Single-molecule measurements of DNA twist and extension have been used to reveal
physical properties of the double helix and to characterize structural dynamics and …
physical properties of the double helix and to characterize structural dynamics and …
Revealing transient structures of nucleosomes as DNA unwinds
The modulation of DNA accessibility by nucleosomes is a fundamental mechanism of gene
regulation in eukaryotes. The nucleosome core particle (NCP) consists of 147 bp of DNA …
regulation in eukaryotes. The nucleosome core particle (NCP) consists of 147 bp of DNA …