Molecular Landscape of LncRNAs in Prostate Cancer: A focus on pathways and therapeutic targets for intervention
S Mirzaei, MDA Paskeh, E Okina, MH Gholami… - Journal of Experimental …, 2022 - Springer
Background One of the most malignant tumors in men is prostate cancer that is still incurable
due to its heterogenous and progressive natures. Genetic and epigenetic changes play …
due to its heterogenous and progressive natures. Genetic and epigenetic changes play …
WNT as a driver and dependency in cancer
The WNT signaling pathway is a critical regulator of development and adult tissue
homeostasis and becomes dysregulated in many cancer types. Although hyperactivation of …
homeostasis and becomes dysregulated in many cancer types. Although hyperactivation of …
[HTML][HTML] Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients
Metastatic progression is the main cause of death in cancer patients, whereas the
underlying genomic mechanisms driving metastasis remain largely unknown. Here, we …
underlying genomic mechanisms driving metastasis remain largely unknown. Here, we …
Chromatin profiles classify castration-resistant prostate cancers suggesting therapeutic targets
In castration-resistant prostate cancer (CRPC), the loss of androgen receptor (AR)
dependence leads to clinically aggressive tumors with few therapeutic options. We used …
dependence leads to clinically aggressive tumors with few therapeutic options. We used …
Multiomic analysis of lung tumors defines pathways activated in neuroendocrine transformation
A Quintanal-Villalonga, H Taniguchi, YA Zhan… - Cancer discovery, 2021 - AACR
Lineage plasticity is implicated in treatment resistance in multiple cancers. In lung
adenocarcinomas (LUAD) amenable to targeted therapy, transformation to small cell lung …
adenocarcinomas (LUAD) amenable to targeted therapy, transformation to small cell lung …
Senescence induction dictates response to chemo-and immunotherapy in preclinical models of ovarian cancer
SV Paffenholz, C Salvagno, YJ Ho… - Proceedings of the …, 2022 - National Acad Sciences
High-grade serous ovarian carcinoma (HGSOC) is a cancer with dismal prognosis due to
the limited effectiveness of existing chemo-and immunotherapies. To elucidate mechanisms …
the limited effectiveness of existing chemo-and immunotherapies. To elucidate mechanisms …
Generation of precision preclinical cancer models using regulated in vivo base editing
Although single-nucleotide variants (SNVs) make up the majority of cancer-associated
genetic changes and have been comprehensively catalogued, little is known about their …
genetic changes and have been comprehensively catalogued, little is known about their …
A MYC and RAS co-activation signature in localized prostate cancer drives bone metastasis and castration resistance
Understanding the intricacies of lethal prostate cancer poses specific challenges due to
difficulties in accurate modeling of metastasis in vivo. Here we show that NPK EYFP mice …
difficulties in accurate modeling of metastasis in vivo. Here we show that NPK EYFP mice …
Genomic control of metastasis
SA Patel, P Rodrigues, L Wesolowski… - British Journal of …, 2021 - nature.com
Metastasis remains the leading cause of cancer-associated mortality, and a detailed
understanding of the metastatic process could suggest new therapeutic avenues. However …
understanding of the metastatic process could suggest new therapeutic avenues. However …
Condensate-Promoting ENL Mutation Drives Tumorigenesis In Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression
Gain-of-function mutations in the histone acetylation “reader” eleven-nineteen-leukemia
(ENL), found in acute myeloid leukemia (AML) and Wilms tumor, are known to drive …
(ENL), found in acute myeloid leukemia (AML) and Wilms tumor, are known to drive …