Short interfering RNAs (siRNA) are a powerful class of genetic medicines whose clinical
translation can be hindered by their suboptimal delivery properties in vivo. Here, we provide …

Over the past few decades, pathogens have posed a threat to human security, and rapid
identification of pathogens should be one of the ideal methods to prevent major public …

Preclinical mechanistic studies have pointed towards RNA interference-mediated off-target
effects as a major driver of hepatotoxicity for GalNAc–siRNA conjugates. Here, we …

Mechanical interactions between cells and extracellular matrix (ECM) are critical for stem
cell fate decision. Synthetic models of ECM, such as hydrogels, can be used to precisely …

Adjuvants are of critical value in vaccine development as they act on enhancing
immunogenicity of antigen and inducing long‐lasting immunity. However, there are only a …

CRISPR-Cas12a is a leading technology for development of model organisms, therapeutics,
and diagnostics. These applications could benefit from chemical modifications that stabilize …

Herein, we have demonstrated that the siRNA activity could be enhanced by incorporating
the guide strand in the RISC complex through thermodynamic asymmetry caused by m3U …

Site-specific incorporation of 2′-modifications and neutral linkages in the deoxynucleotide
gap region of toxic phosphorothioate (PS) gapmer ASOs can enhance therapeutic index and …

Small extracellular vesicles (sEVs) are promising nanocarriers for drug delivery to treat a
wide range of diseases due to their natural origin and innate homing properties. However …

Therapeutic small interfering RNAs (siRNAs) are double stranded RNAs capable of potent
and specific gene silencing through activation of the RNA interference (RNAi) pathway. The …