Caution when diagnosing your mouse with schizophrenia: the use and misuse of model animals for understanding psychiatric disorders

AHC Wong, SA Josselyn - Biological psychiatry, 2016 - Elsevier
Animal models are widely used in biomedical research, but their applicability to psychiatric
disorders is less clear. There are several reasons for this, including 1) emergent features of …

Pro-nociceptive action of cholecystokinin in the periaqueductal grey: a role in neuropathic and anxiety-induced hyperalgesic states

TA Lovick - Neuroscience & Biobehavioral Reviews, 2008 - Elsevier
The perception of pain is a dynamic process that is subject to ongoing modulation by central
pro-and anti-nociceptive control systems. Diverse factors that may be genetic, gender …

High-novelty-preference rats are predisposed to compulsive cocaine self-administration

D Belin, N Berson, E Balado, PV Piazza… - …, 2011 - nature.com
Sensation/novelty-seeking is amongst the best markers of cocaine addiction in humans.
However, its implication in the vulnerability to cocaine addiction is still a matter of debate, as …

Adolescent male rats exposed to social defeat exhibit altered anxiety behavior and limbic monoamines as adults.

MJ Watt, AR Burke, KJ Renner… - Behavioral …, 2009 - psycnet.apa.org
Social stress in adolescence is correlated with emergence of psychopathologies during
early adulthood. In this study, the authors investigated the impact of social defeat stress …

CCK reduces the food intake mainly through CCK1R in Siberian sturgeon (Acipenser baerii Brandt)

X Zhang, N Tang, J Qi, S Wang, J Hao, Y Wu, H Chen… - Scientific reports, 2017 - nature.com
To explore the effect of CCK on food intake in Siberian sturgeon, cck cDNA sequence of
1005 bp was obtained, and cck mRNA possessed the highest expression in brain. The …

Cholecystokinin-mediated neuromodulation of anxiety and schizophrenia: a “dimmer-switch” hypothesis

SJ Ballaz, M Bourin - Current Neuropharmacology, 2021 - ingentaconnect.com
Cholecystokinin (CCK), the most abundant brain neuropeptide, is involved in relevant
behavioral functions like memory, cognition, and reward through its interactions with the …

Individual differences in novelty-seeking and behavioral responses to nicotine: a review of animal studies

R Redolat, A Pérez-Martínez… - Current drug abuse …, 2009 - ingentaconnect.com
Individual differences in the behavioral responses to a novel environment have been
proposed as a research tool to predict responsiveness to other behavioral tasks, response to …

Does endogenous cholecystokinin modulate alcohol intake?

S Ballaz, N Espinosa, M Bourin - Neuropharmacology, 2021 - Elsevier
Alcohol use disorder or alcoholism is characterized by uncontrollable alcohol use and
intoxication, as well as a heightened state of anxiety after alcohol withdrawal. Ethanol …

Blockade of the cholecystokinin CCK-2 receptor prevents the normalization of anxiety levels in the rat

SJ Ballaz, M Bourin, H Akil, SJ Watson - Progress in Neuro …, 2020 - Elsevier
Cholecystokinin (CCK), through the CCK-2 receptor, exerts complex effects on anxiety.
While CCK agonists are panicogenic, CCK-2 antagonists fail to alleviate human anxiety …

Effect of cocaine on Fas-associated protein with death domain in the rat brain: individual differences in a model of differential vulnerability to drug abuse

MJ García-Fuster, SM Clinton, SJ Watson… - …, 2009 - nature.com
This study was designed to (1) assess the effects of cocaine on Fas-associated protein with
death domain (FADD) system and its role in the activation of apoptotic vs nonapoptotic …