Background: Lactate dehydrogenase (LDH) is a group of oxidoreductase isoenzymes
catalyzing the reversible reaction between pyruvate and lactate. The five isoforms of this …

Human lactate dehydrogenase (h LDH5), a glycolytic enzyme responsible for the conversion
of pyruvate to lactate coupled with oxidation of NADH to NAD+, plays a crucial role in the …

Metabolic reprogramming in tumors represents a potential therapeutic target. Herein we
used shRNA depletion and a novel lactate dehydrogenase (LDHA) inhibitor, GNE-140, to …

We report the discovery and medicinal chemistry optimization of a novel series of pyrazole-
based inhibitors of human lactate dehydrogenase (LDH). Utilization of a quantitative high …

Almost all invasive cancers, regardless of tissue origin, are characterized by specific
modifications of their cellular energy metabolism. In fact, a strong predominance of aerobic …

Although immunotherapy plays a significant role in tumor therapy, its efficacy is impaired by
an immunosuppressive tumor microenvironment. A molecule that contributes to the protumor …

It is unresolved why lactate is transported to the liver for further utilization within the
physiological purview of Cori cycle, when muscles have more lactate dehydrogenase (LDH) …

Lactate dehydrogenase (LDH) catalyzes the conversion of pyruvate to lactate, with
concomitant oxidation of reduced nicotinamide adenine dinucleotide as the final step in the …

Background Liver is the largest internal organ concerning with metabolism, hormonal
balance and clarifying of the toxins. One of the main complications of methotrexate (MTX) …

Dysregulated metabolism is one of the hallmarks of cancer. Under normal physiological
conditions, ATP is primarily generated by oxidative phosphorylation. Cancers commonly …