Background Gene delivery systems are essentially necessary for the gene therapy of human
genetic diseases. Gene therapy is the unique way that is able to use the adjustable gene to …

Hematopoietic stem-cell transplantation, which is used to treat both malignant and
nonmalignant conditions, was first conceived more than 50 years ago, but problems …

Acute myeloid leukemia (AML) is characterized by an increase in the number of myeloid
cells in the marrow and an arrest in their maturation, frequently resulting in hematopoietic …

Although improvement in outcomes has occurred in younger adults with acute myeloid
leukemia (AML) during the past 4 decades, progress in older adults has been much less …

Over the last 60 years, more than a million patients received hematopoietic cell
transplantation. Having incorporated multiple changes in clinical practices, it remains a …

Adenosine deaminase (ADA) deficiency results in severe combined immunodeficiency, the
first genetic disorder treated by gene therapy. Two different retroviral vectors were used to …

''It seems more than ever likely that blood-derived stem tive capacity. 47-49 In the allogeneic
setting, mobilized blood cells have also been used instead of BM. 50 Umbilical cord cells …

Colloidal quantum dots are semiconductor nanocrystals well dispersed in a solvent. The
optical properties of quantum dots, in particular the wavelength of their fluorescence …

The introduction and expression of genes in somatic cells is an innovative therapy for
correcting genetic deficiency diseases and augmenting immune function. A potential …

The childhood leukemias are a study in contrasts. Acute lymphoblastic leukemia (ALL) is
diagnosed in approximately 2000 children in the United States each year, whereas acute …