The entorhinal cortex (EC) is the brain region that often exhibits the earliest histological
alterations in Alzheimer's disease (AD), including the formation of neurofibrillary tangles and …

It is proposed that a cognitive map encoding the relationships between entities in the world
supports flexible behavior, but the majority of the neural evidence for such a system comes …

The dentate gyrus (DG) has a key role in hippocampal memory formation. Intriguingly, DG
lesions impair many, but not all, hippocampus-dependent mnemonic functions, indicating …

INTRODUCTION Learning induces a dynamic reorganization of brain circuits but the
neuronal mechanisms underlying this process are not well understood. Interregional gamma …

To understand brain function, it is essential that we discover how cellular signaling specifies
normal and pathological brain function. In this regard, chemogenetic technologies represent …

Since the first place cell was recorded and the cognitive-map theory was subsequently
formulated, investigation of spatial representation in the hippocampal formation has evolved …

Reversible silencing of neuronal activity is a powerful approach for isolating the roles of
specific neuronal populations in circuit dynamics and behavior. In contrast with neuronal …

Memories are believed to be encoded by sparse ensembles of neurons in the brain.
However, it remains unclear whether there is functional heterogeneity within individual …

Patients with Alzheimer's disease (AD) suffer from spatial memory impairment and
wandering behavior, but the brain circuit mechanisms causing such symptoms remain …

The mammalian hippocampus is critical for spatial information processing and episodic
memory. Its primary output cells, CA1 pyramidal cells (CA1 PCs), vary in genetics …