New drugs are urgently needed for the treatment of tropical and subtropical parasitic
diseases, such as African sleeping sickness, Chagas' disease, leishmaniasis and malaria …

Parasites of the genus Leishmania cause a variety of devastating and often fatal diseases in
humans and domestic animals worldwide. The need for new therapeutic strategies is urgent …

Chagas disease (CD) affects at least 6 million people in 21 South American countries
besides several thousand in other nations all over the world. It is estimated that at least …

Despite ongoing efforts, the current treatment for Chagas disease is still unsatisfactory,
mainly because of the severe side effects and variable efficacy of the available …

It has been over a century since Carlos Chagas discovered the Trypanosoma cruzi (T. cruzi)
as the causative agent of Chagas disease (CD), a neglected tropical disease with several …

The plant Cecropia pachystachya Trécul is widely used in Brazilian ethnomedicine to treat
hypertension, asthma, and diabetes. Arginase is an enzyme with levels that are elevated in …

Electron microscopy may be useful in chemotherapy studies at distinct levels, such as the
identification of subcellular targets in the parasites and the elucidation of the ultimate drug …

Natural products comprise valuable sources for new antiparasitic drugs. Here we tested the
effects of a novel β–lapachone derivative on Trypanosoma cruzi parasite survival and …

Chagas' disease is a debilitating but comparatively neglected illness that affects about 15
million people. There is an urgent need to develop new, more effective, and less-toxic …

Chagas disease or American Trypanosomiasis, a parasitic infection typically spread by
triatomine bugs, affects millions of people throughout Latin America. Current chemotherapy …