Radioactive transition metals for imaging and therapy

E Boros, AB Packard - Chemical reviews, 2018 - ACS Publications
Nuclear medicine is composed of two complementary areas, imaging and therapy. Positron
emission tomography (PET) and single-photon imaging, including single-photon emission …

Radiochemistry: a hot field with opportunities for cool chemistry

GD Bowden, PJH Scott, E Boros - ACS Central Science, 2023 - ACS Publications
Recent Food and Drug Administration (FDA) approval of diagnostic and therapeutic
radiopharmaceuticals and concurrent miniaturization of particle accelerators leading to …

[HTML][HTML] Modulating the pharmacokinetic profile of Actinium-225-labeled macropa-derived radioconjugates by dual targeting of PSMA and albumin

F Reissig, K Zarschler, Z Novy, M Petrik, K Bendova… - Theranostics, 2022 - ncbi.nlm.nih.gov
Abstract Rationale: Small 225 Ac-labeled prostate-specific membrane antigen (PSMA)-
targeted radioconjugates have been described for targeted alpha therapy of metastatic …

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): An Emerging Tool in Radiopharmaceutical Science

KD Klika, J Han, MS Busse… - Journal of the …, 2024 - ACS Publications
Although radioactive experiments are necessary in radiopharmaceutical drug discovery and
theranostic cancer research, they are expensive, require special facilities, and face certain …

Preclinical evaluation of [58mCo]Co-DOTA-PSMA-617 for Auger electron therapy of prostate cancer

C Baun, JH Dam, MG Hildebrandt, JD Ewald… - Scientific Reports, 2023 - nature.com
Prostate-specific membrane antigen (PSMA), highly expressed in prostate cancer, is a
promising target for radionuclide therapy. Auger electron-emitting radionuclides are well …

Towards targeted alpha therapy with actinium-225: chelators for mild condition radiolabeling and targeting PSMA—a proof of concept study

F Reissig, D Bauer, K Zarschler, Z Novy, K Bendova… - Cancers, 2021 - mdpi.com
Simple Summary In nuclear medicine, therapeutic methods are used increasingly, in which
tumors are destroyed by ionizing radiation that cannot or can only be treated insufficiently by …

Radiometals for imaging and theranostics, current production, and future perspectives

R Mikolajczak, NP van der Meulen… - Journal of Labelled …, 2019 - Wiley Online Library
The aim of this review is to make the reader familiar with currently available radiometals,
their production modes, capacities, and quality concerns related to their medical use, as well …

Radiolabeling Diaminosarcophagine with Cyclotron-Produced Cobalt-55 and [55Co]Co-NT-Sarcage as a Proof of Concept in a Murine Xenograft Model

W Lin, GO Fonseca Cabrera… - Bioconjugate …, 2024 - ACS Publications
Cobalt–sarcophagine complexes exhibit high kinetic inertness under various stringent
conditions, but there is limited literature on radiolabeling and in vivo positron emission …

Production, purification, and applications of a potential theranostic pair: cobalt-55 and cobalt-58m

KE Barrett, HA Houson, W Lin, SE Lapi, JW Engle - Diagnostics, 2021 - mdpi.com
The emerging success of [68Ga/177Lu] Ga/Lu-DOTATATE as a theranostic pair has spurred
interest in other isotopes as potential theranostic combinations. Here, we review cobalt-55 …

Expanding PET-applications in life sciences with positron-emitters beyond fluorine-18

HH Coenen, J Ermert - Nuclear medicine and biology, 2021 - Elsevier
Abstract Positron-emission-tomography (PET) has become an indispensable diagnostic tool
in modern nuclear medicine. Its outstanding molecular imaging features allow repetitive …