[HTML][HTML] Genetic markers in triple-negative breast cancer

Z Sporikova, V Koudelakova, R Trojanec… - Clinical breast cancer, 2018 - Elsevier
Triple-negative breast cancer (TNBC) accounts for 15% to 20% of breast cancer cases and
is characterized by the absence of estrogen, progesterone, and human epidermal growth …

[HTML][HTML] Recent therapeutic trends and promising targets in triple negative breast cancer

SY Hwang, S Park, Y Kwon - Pharmacology & therapeutics, 2019 - Elsevier
Breast cancer accounts for 25% of all types of cancer in women, and triple negative breast
cancer (TNBC) comprises around 15~ 20% of breast cancers. Conventional chemotherapy …

[HTML][HTML] Targeting the PI3-kinase pathway in triple-negative breast cancer

J Pascual, NC Turner - Annals of Oncology, 2019 - Elsevier
Triple-negative breast cancer (TNBC) is characterised by poor outcomes and a historical
lack of targeted therapies. Dysregulation of signalling through the phosphoinositide 3 (PI3) …

[HTML][HTML] Loss of PTEN expression in breast cancer: association with clinicopathological characteristics and prognosis

S Li, Y Shen, M Wang, J Yang, M Lv, P Li, Z Chen… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Various studies have evaluated the significance of PTEN (phosphatase and tensin homolog
deleted from chromosome 10) expression in breast cancer, but their results remain …

Reciprocal regulation of Hsa-miR-1 and long noncoding RNA MALAT1 promotes triple-negative breast cancer development

C Jin, B Yan, Q Lu, Y Lin, L Ma - Tumor Biology, 2016 - Springer
Recent studies demonstrated that long noncoding RNAs (lncRNAs) have a critical role in the
regulation of cancer progression and metastasis. However, little is known about the …

Differential expression of PD-L1 between primary and metastatic epithelial ovarian cancer and its clinico-pathological correlation

SK Parvathareddy, AK Siraj, IA Al-Badawi, A Tulbah… - Scientific Reports, 2021 - nature.com
Ovarian cancer (OC) is one of the most common gynecologic cancer, which has the worst
prognosis and highest mortality rate. The lack of curative treatment and the high relapse …

MicroRNAs in the prognosis of triple-negative breast cancer: A systematic review and meta-analysis

L Lü, X Mao, P Shi, B He, K Xu, S Zhang, J Wang - Medicine, 2017 - journals.lww.com
Background: Triple-negative breast cancer (TNBC) is a heterogeneous group of tumors
characterized by their aggressive nature and poor associated survival. MicroRNAs (miRs) …

Role of PTEN, PI3K, and mTOR in triple-negative breast cancer

M Prvanović, M Nedeljković, N Tanić, T Tomić, T Terzić… - Life, 2021 - mdpi.com
Breast cancer is the most commonly occurring malignancy and the leading cause of cancer-
related death in women. Triple-negative breast cancer (TNBC) is the most aggressive …

Current advances in biomarkers for targeted therapy in triple-negative breast cancer

B Fleisher, C Clarke, S Ait-Oudhia - Breast Cancer: Targets and …, 2016 - Taylor & Francis
Triple-negative breast cancer (TNBC) is a complex heterogeneous disease characterized by
the absence of three hallmark receptors: human epidermal growth factor receptor 2 …

Phosphorylation of Rab7 by TBK1/IKKϵ regulates innate immune signaling in triple-negative breast cancer

JL Ritter, Z Zhu, TC Thai, NR Mahadevan, P Mertins… - Cancer research, 2020 - AACR
Triple-negative breast cancer (TNBC) is a heterogeneous disease enriched for mutations in
PTEN and dysregulation of innate immune signaling. Here, we demonstrate that Rab7, a …