Vascular mechanotransduction
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
General pathways of pain sensation and the major neurotransmitters involved in pain regulation
Pain has been considered as a concept of sensation that we feel as a reaction to the
stimulus of our surrounding, putting us in harm's way and acting as a form of defense …
stimulus of our surrounding, putting us in harm's way and acting as a form of defense …
Neurobiology of fibromyalgia and chronic widespread pain
Fibromyalgia is the current term for chronic widespread musculoskeletal pain for which no
alternative cause can be identified. The underlying mechanisms, in both human and animal …
alternative cause can be identified. The underlying mechanisms, in both human and animal …
Cellular and molecular mechanisms of pain
AI Basbaum, DM Bautista, G Scherrer, D Julius - Cell, 2009 - cell.com
The nervous system detects and interprets a wide range of thermal and mechanical stimuli,
as well as environmental and endogenous chemical irritants. When intense, these stimuli …
as well as environmental and endogenous chemical irritants. When intense, these stimuli …
Acid-sensing ion channels in pain and disease
Why do neurons sense extracellular acid? In large part, this question has driven increasing
investigation on acid-sensing ion channels (ASICs) in the CNS and the peripheral nervous …
investigation on acid-sensing ion channels (ASICs) in the CNS and the peripheral nervous …
Nociceptor sensitization in pain pathogenesis
MS Gold, GF Gebhart - Nature medicine, 2010 - nature.com
The incidence of chronic pain is estimated to be 20–25% worldwide. Few patients with
chronic pain obtain complete relief from the drugs that are currently available, and more than …
chronic pain obtain complete relief from the drugs that are currently available, and more than …
The biopsychosocial approach to chronic pain: scientific advances and future directions.
The prevalence and cost of chronic pain is a major physical and mental health care problem
in the United States today. As a result, there has been a recent explosion of research on …
in the United States today. As a result, there has been a recent explosion of research on …
Epithelial sodium channel (ENaC) family: Phylogeny, structure–function, tissue distribution, and associated inherited diseases
I Hanukoglu, A Hanukoglu - Gene, 2016 - Elsevier
The epithelial sodium channel (ENaC) is composed of three homologous subunits and
allows the flow of Na+ ions across high resistance epithelia, maintaining body salt and water …
allows the flow of Na+ ions across high resistance epithelia, maintaining body salt and water …
Calcium-permeable ion channels in pain signaling
The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …
dependent on a wide range of different types of voltage-and ligand-gated ion channels …
Molecular mechanisms of mechanotransduction in mammalian sensory neurons
P Delmas, J Hao, L Rodat-Despoix - Nature Reviews Neuroscience, 2011 - nature.com
The somatosensory system mediates fundamental physiological functions, including the
senses of touch, pain and proprioception. This variety of functions is matched by a diverse …
senses of touch, pain and proprioception. This variety of functions is matched by a diverse …