This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Pain has been considered as a concept of sensation that we feel as a reaction to the
stimulus of our surrounding, putting us in harm's way and acting as a form of defense …

Fibromyalgia is the current term for chronic widespread musculoskeletal pain for which no
alternative cause can be identified. The underlying mechanisms, in both human and animal …

The nervous system detects and interprets a wide range of thermal and mechanical stimuli,
as well as environmental and endogenous chemical irritants. When intense, these stimuli …

Why do neurons sense extracellular acid? In large part, this question has driven increasing
investigation on acid-sensing ion channels (ASICs) in the CNS and the peripheral nervous …

The incidence of chronic pain is estimated to be 20–25% worldwide. Few patients with
chronic pain obtain complete relief from the drugs that are currently available, and more than …

The prevalence and cost of chronic pain is a major physical and mental health care problem
in the United States today. As a result, there has been a recent explosion of research on …

The epithelial sodium channel (ENaC) is composed of three homologous subunits and
allows the flow of Na+ ions across high resistance epithelia, maintaining body salt and water …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

The somatosensory system mediates fundamental physiological functions, including the
senses of touch, pain and proprioception. This variety of functions is matched by a diverse …