Catalytic stereoselective multicomponent reactions for the synthesis of spiro derivatives: recent progress
Spiro derivatives are important scaffolding substances found in many natural products and
pharmaceuticals. In the last decade, numerous new approaches based on multicomponent …
pharmaceuticals. In the last decade, numerous new approaches based on multicomponent …
Recent synthetic strategies of spiro-azetidin-2-one,-pyrrolidine,-indol (one) and-pyran derivatives-a review
Spiro-heterocycles have received special attention in medicinal chemistry because of their
promising biological activity. Over the years, many synthetic methodologies have been …
promising biological activity. Over the years, many synthetic methodologies have been …
Synthesis, in-vitro biological evaluation, and molecular docking study of novel spiro-β-lactam-isatin hybrids
A Jarrahpour, Z Jowkar, Z Haghighijoo… - Medicinal Chemistry …, 2022 - Springer
In our ongoing search for bioactive compounds, a class of novel spiro-β-lactam isatin
hybrids has been synthesized through a [2+ 2] cycloaddition reaction from 1-allyl-3 …
hybrids has been synthesized through a [2+ 2] cycloaddition reaction from 1-allyl-3 …
An Energetic and Topological Approach to Understanding the Interplay of Noncovalent Interactions in a Series of Crystalline Spiropyrrolizine Compounds
Synthesis of quinoline-containing spiropyrrolizine was achieved via a 1, 3-dipolar
cycloaddition reaction of azomethine ylide (generated in situ from ninhydrin and l-proline) …
cycloaddition reaction of azomethine ylide (generated in situ from ninhydrin and l-proline) …
Spiral molecules with antimalarial activities: A review
J Yang, Y Wang, W Guan, W Su, G Li, S Zhang… - European Journal of …, 2022 - Elsevier
Malaria is a prevalent fatal disease in tropical and subtropical regions around the world.
Combinations of Artemisinin, folate antagonists, quinolines, and antibiotics are major …
Combinations of Artemisinin, folate antagonists, quinolines, and antibiotics are major …
C7‐Halomethylene/methyl‐C3‐thiophenyl‐spirocyclic‐β‐lactams: Synthesis, X‐ray Analysis, Antimicrobial Evaluation, Cytotoxicity Profile and Molecular Docking …
In the realm of healthcare, the continuous evolution of new alternative antimicrobial agents
provides hope in addressing the progressively daunting issue of severe multidrug …
provides hope in addressing the progressively daunting issue of severe multidrug …
Exploring the recent pioneering developments of small molecules in antimalarial drug armamentarium: A chemistry prospective appraisal
T Bagratee, R Prawlall, T Ndlovu, S Sibisi… - Chemistry & …, 2024 - Wiley Online Library
Malaria is a very destructive and lethal parasitic disease that causes significant mortality
worldwide, resulting in the loss of millions of lives annually. It is an infectious disease …
worldwide, resulting in the loss of millions of lives annually. It is an infectious disease …
Unveiling a family of spiro-β-lactams with anti-HIV and antiplasmodial activity via phosphine-catalyzed [3+2] annulation of 6-alkylidene-penicillanates and allenoates
The molecular architecture of spirocyclic compounds has been widely explored within the
medicinal chemistry field to obtain new compounds with singular three-dimensional …
medicinal chemistry field to obtain new compounds with singular three-dimensional …
Synthesis of novel chiral spiro-β-lactams from nitrile oxides and 6-(Z)-(benzoylmethylene) penicillanate: batch, microwave-induced and continuous flow …
AJS Alves, JAD Silvestre, TMVDP e Melo - RSC advances, 2022 - pubs.rsc.org
The first examples of the diastereoselective 1, 3-dipolar cycloaddition reaction of nitrile
oxides and 6-alkylidene penicillanates leading to chiral spiroisoxazoline-penicillanates are …
oxides and 6-alkylidene penicillanates leading to chiral spiroisoxazoline-penicillanates are …
Insights into the anticancer activity of chiral alkylidene-β-lactams and alkylidene-γ-lactams: Synthesis and biological investigation
Chiral alkylidene-β-lactams and alkylidene-γ-lactams were synthesized and screened for
their in vitro activity against four human cancer cell lines (melanoma, esophageal, lung and …
their in vitro activity against four human cancer cell lines (melanoma, esophageal, lung and …