[HTML][HTML] An overview of the biological evaluation of selected nitrogen-containing heterocycle medicinal chemistry compounds
O Ebenezer, MA Jordaan, G Carena, T Bono… - International Journal of …, 2022 - mdpi.com
Heterocyclic compounds are a class of compounds of natural origin with favorable
properties and hence have major pharmaceutical significance. They have an exceptional …
properties and hence have major pharmaceutical significance. They have an exceptional …
Exploration of 1, 2, 3-triazole linked benzenesulfonamide derivatives as isoform selective inhibitors of human carbonic anhydrase
Abstract A novel series of 1, 2, 3-triazole benzenesulfonamide substituted 1, 3-
dioxoisoindolin-5-carboxylate (7a-l) inhibitors of human α-carbonic anhydrase (hCA) was …
dioxoisoindolin-5-carboxylate (7a-l) inhibitors of human α-carbonic anhydrase (hCA) was …
Discovery of novel benzenesulfonamides incorporating 1, 2, 3-triazole scaffold as carbonic anhydrase I, II, IX, and XII inhibitors
Sulfonamides are among the most promising potential inhibitors for carbonic anhydrases
(CAs), which are pharmaceutically relevant targets for treating several disease conditions …
(CAs), which are pharmaceutically relevant targets for treating several disease conditions …
[HTML][HTML] Cytotoxic effect, enzyme inhibition, and in silico studies of some novel N-substituted sulfonyl amides incorporating 1,3,4-oxadiazol structural motif
The acetylcholinesterase and carbonic anhydrase inhibitors (AChEIs and h CAIs) remain
key therapeutic agents for many bioactivities such as anti-Alzheimer and antiobesity …
key therapeutic agents for many bioactivities such as anti-Alzheimer and antiobesity …
Design, synthesis, biological evaluation and molecular docking studies of novel 1H-1, 2, 3-Triazole derivatives as potent inhibitors of carbonic anhydrase …
Triazole compounds have garnered significant interest due to their wide range of
pharmacological activities and ease of synthesis. Click chemistry is a synthetic method …
pharmacological activities and ease of synthesis. Click chemistry is a synthetic method …
Novel beta-lactam substituted benzenesulfonamides: in vitro enzyme inhibition, cytotoxic activity and in silico interactions
In this study, a library of twelve beta-lactam-substituted benzenesulfonamides (5a–l) was
synthesized using the tail-approach method. The compounds were characterized using IR …
synthesized using the tail-approach method. The compounds were characterized using IR …
Design, synthesis, and biological activity of novel dithiocarbamate‐methylsulfonyl hybrids as carbonic anhydrase inhibitors
Carbonic anhydrase (CA) enzymes are involved in many physiological events. These
enzymes, which contain Zn2+ in their structure, can be easily inhibited by dithiocarbamate …
enzymes, which contain Zn2+ in their structure, can be easily inhibited by dithiocarbamate …
Novel metabolic enzyme inhibitors designed through the molecular hybridization of thiazole and pyrazoline scaffolds
New hybrid thiazolyl–pyrazoline derivatives (4a–k) were obtained through a facile and
versatile synthetic procedure, and their inhibitory effects on the human carbonic anhydrase …
versatile synthetic procedure, and their inhibitory effects on the human carbonic anhydrase …
Molecular docking and inhibition studies of vulpinic, carnosic and usnic acids on polyol pathway enzymes
Aldose reductase (AR) and sorbitol dehydrogenase (SDH) are important enzymes of the
polyol pathway. In the current study, inhibitory effects of vulpinic acid (VA) carnosic acid (CA) …
polyol pathway. In the current study, inhibitory effects of vulpinic acid (VA) carnosic acid (CA) …
Thiadiazole–A promising structure in design and development of anti-Alzheimer agents
M Hatami, Z Basri, BK Sakhvidi, M Mortazavi - International …, 2023 - Elsevier
The design and development of effective multitargeted agents in treating Alzheimer disease
(AD) has always been a hot topic in the field of drug discovery. Since AD is a multifactorial …
(AD) has always been a hot topic in the field of drug discovery. Since AD is a multifactorial …