The protozoan diseases Human African Trypanosomiasis (HAT), Chagas disease (CD), and
leishmaniases span worldwide and therefore their impact is a universal concern. The …

The twentieth century ended with human African trypanosomiasis (HAT) epidemics raging
across many parts of Africa. Resistance to existing drugs was emerging, and many programs …

Background Human African trypanosomiasis (HAT), also known as sleeping sickness, is a
fatal parasitic disease caused by trypanosomes. Current treatment options for HAT are …

African sleeping sickness or human African trypanosomiasis, caused by Trypanosoma
brucei spp., is responsible for∼ 30,000 deaths each year. Available treatments for this …

Trypanosomes are important disease agents and excellent models for the study of
evolutionary cell biology. The trypanosome flagellar pocket is a small invagination of the …

As the carrier of genetic information, the DNA double helix interacts with many natural
ligands during the cell cycle, and is amenable to such intervention in diseases such as …

Fexinidazole is a 5-nitroimidazole drug currently in clinical development for the treatment of
human sleeping sickness (human African trypanosomiasis [HAT]), caused by infection with …

In this study, thirteen sponge-derived terpenoids, including five linear furanoterpenes:
furospinulosin-1 (1), furospinulosin-2 (2), furospongin-1 (3), furospongin-4 (4), and …

Novel dicationic triazoles 1− 60 were synthesized by the Pinner method from the
corresponding dinitriles, prepared via the copper (I)-catalyzed azide− alkyne cycloaddition …

African sleeping sickness is endemic in sub-Saharan Africa where the WHO estimates that
60 million people are at risk for the disease. Human African trypanosomiasis (HAT) is 100 …