Stem cell-derived models of spinal neurulation

C Mirdass, M Catala, M Bocel… - Emerging Topics in …, 2023 - portlandpress.com
Neurulation is a critical step in early embryonic development, giving rise to the neural tube,
the primordium of the central nervous system in amniotes. Understanding this complex, multi …

[HTML][HTML] Focus: Cell Fate: Advances in Regulating Cellular Behavior Using Micropatterns

Y Li, W Jiang, X Zhou, Y Long, Y Sun… - The Yale Journal of …, 2023 - ncbi.nlm.nih.gov
Micropatterns, characterized as distinct physical microstructures or chemical adhesion
matrices on substance surfaces, have emerged as a powerful tool for manipulating cellular …

Advancements in 2D and 3D In Vitro Models for Studying Neuromuscular Diseases

H Kim, GS Kim, SH Hyun, E Kim - International Journal of Molecular …, 2023 - mdpi.com
Neuromuscular diseases (NMDs) are a genetically or clinically heterogeneous group of
diseases that involve injury or dysfunction of neuromuscular tissue components, including …

Design of neural organoids engineered by mechanical forces

DNA Suong, K Imamura, Y Kato, H Inoue - IBRO Neuroscience Reports, 2024 - Elsevier
Neural organoids consist of three-dimensional tissue derived from pluripotent stem cells that
could recapitulate key features of the human brain. During the past decade, organoid …

The Differential Developmental Neurotoxicity of Valproic Acid on Anterior and Posterior Neural Induction of Human Pluripotent Stem Cells

J Kim, SH Park, W Sun - International Journal of Stem Cells, 2024 - ijstemcell.com
Valproic acid (VPA), widely used as an antiepileptic drug, exhibits developmental
neurotoxicity when exposure occurs during early or late pregnancy, resulting in various …

[HTML][HTML] Polarization of organoids by bioengineered symmetry breaking

JR Ryu, K Ko, W Sun - IBRO Neuroscience Reports, 2024 - Elsevier
Symmetry breaking leading to axis formation and spatial patterning is crucial for achieving
more accurate recapitulation of human development in organoids. While these processes …

Chronic opioid treatment arrests neurodevelopment and alters synaptic activity in human midbrain organoids

HS Kim, Y Xiao, X Chen, S He, J Im… - Advanced …, 2024 - Wiley Online Library
Understanding the impact of long‐term opioid exposure on the embryonic brain is critical
due to the surging number of pregnant mothers with opioid dependency. However, this has …