Stem cell-derived models of spinal neurulation
C Mirdass, M Catala, M Bocel… - Emerging Topics in …, 2023 - portlandpress.com
Neurulation is a critical step in early embryonic development, giving rise to the neural tube,
the primordium of the central nervous system in amniotes. Understanding this complex, multi …
the primordium of the central nervous system in amniotes. Understanding this complex, multi …
[HTML][HTML] Focus: Cell Fate: Advances in Regulating Cellular Behavior Using Micropatterns
Y Li, W Jiang, X Zhou, Y Long, Y Sun… - The Yale Journal of …, 2023 - ncbi.nlm.nih.gov
Micropatterns, characterized as distinct physical microstructures or chemical adhesion
matrices on substance surfaces, have emerged as a powerful tool for manipulating cellular …
matrices on substance surfaces, have emerged as a powerful tool for manipulating cellular …
Advancements in 2D and 3D In Vitro Models for Studying Neuromuscular Diseases
H Kim, GS Kim, SH Hyun, E Kim - International Journal of Molecular …, 2023 - mdpi.com
Neuromuscular diseases (NMDs) are a genetically or clinically heterogeneous group of
diseases that involve injury or dysfunction of neuromuscular tissue components, including …
diseases that involve injury or dysfunction of neuromuscular tissue components, including …
Design of neural organoids engineered by mechanical forces
DNA Suong, K Imamura, Y Kato, H Inoue - IBRO Neuroscience Reports, 2024 - Elsevier
Neural organoids consist of three-dimensional tissue derived from pluripotent stem cells that
could recapitulate key features of the human brain. During the past decade, organoid …
could recapitulate key features of the human brain. During the past decade, organoid …
The Differential Developmental Neurotoxicity of Valproic Acid on Anterior and Posterior Neural Induction of Human Pluripotent Stem Cells
J Kim, SH Park, W Sun - International Journal of Stem Cells, 2024 - ijstemcell.com
Valproic acid (VPA), widely used as an antiepileptic drug, exhibits developmental
neurotoxicity when exposure occurs during early or late pregnancy, resulting in various …
neurotoxicity when exposure occurs during early or late pregnancy, resulting in various …
[HTML][HTML] Polarization of organoids by bioengineered symmetry breaking
JR Ryu, K Ko, W Sun - IBRO Neuroscience Reports, 2024 - Elsevier
Symmetry breaking leading to axis formation and spatial patterning is crucial for achieving
more accurate recapitulation of human development in organoids. While these processes …
more accurate recapitulation of human development in organoids. While these processes …
Chronic opioid treatment arrests neurodevelopment and alters synaptic activity in human midbrain organoids
Understanding the impact of long‐term opioid exposure on the embryonic brain is critical
due to the surging number of pregnant mothers with opioid dependency. However, this has …
due to the surging number of pregnant mothers with opioid dependency. However, this has …