Sperm DNA fragmentation testing: Summary evidence and clinical practice recommendations

SC Esteves, A Zini, RM Coward, DP Evenson… - Andrologia, 2021 - Wiley Online Library
We herein summarise the evidence concerning the impact of sperm DNA fragmentation in
various clinical infertility scenarios and the advances on sperm DNA fragmentation tests …

Radiations and male fertility

KK Kesari, A Agarwal, R Henkel - Reproductive Biology and …, 2018 - Springer
During recent years, an increasing percentage of male infertility has to be attributed to an
array of environmental, health and lifestyle factors. Male infertility is likely to be affected by …

Role of sperm chromatin abnormalities and DNA damage in male infertility

A Agarwal, TM Said - Human reproduction update, 2003 - academic.oup.com
Sperm DNA integrity is essential for the accurate transmission of genetic information. It has a
highly compact and complex structure and is capable of decondensation—features that must …

[HTML][HTML] Negative effects of increased sperm DNA damage in relation to seminal oxidative stress in men with idiopathic and male factor infertility

RA Saleh, A Agarwal, EA Nada, MH El-Tonsy… - Fertility and sterility, 2003 - Elsevier
OBJECTIVE: To examine the effects of increased sperm DNA damage in relation to seminal
oxidative stress in men with idiopathic and male factor infertility. DESIGN: Prospective study …

Sperm DNA damage in male infertility: etiologies, assays, and outcomes

RT Schulte, DA Ohl, M Sigman, GD Smith - Journal of assisted …, 2010 - Springer
Male factor infertility is the sole cause of infertility in approximately 20% of infertile couples,
with an additional 30% to 40% secondary to both male and female factors. Current means of …

Sperm DNA fragmentation is increased in couples with unexplained recurrent pregnancy loss

DT Carrell, L Liu, CM Peterson, KP Jones… - Archives of …, 2003 - Taylor & Francis
Previous studies have indicated that sperm quality may be related to unexplained recurrent
pregnancy loss. This study evaluated the degree of sperm DNA fragmentation using the …

Comparison of chromatin assays for DNA fragmentation evaluation in human sperm

KR Chohan, JT Griffin, M Lafromboise… - Journal of …, 2006 - Wiley Online Library
Sperm chromatin integrity is vital for successful pregnancy and transmission of genetic
material to the offspring. We evaluated chromatin integrity in sperm from 60 infertile men and …

[PDF][PDF] Apoptosis, spermatogenesis and male infertility

KK Shukla, AA Mahdi… - Frontiers in Bioscience …, 2012 - article.imrpress.com
Introduction 3. Germ Cell Apoptosis 4. Sperm Apoptosis 5. Apoptosis in cryptorchid testis 6.
Oxidative stress and apoptosis 7. Apoptosis and male infertility 8. Apoptosis and male …

[HTML][HTML] Evaluation of nuclear DNA damage in spermatozoa from infertile men with varicocele

RA Saleh, A Agarwal, RK Sharma, TM Said, SC Sikka… - Fertility and sterility, 2003 - Elsevier
OBJECTIVE: To examine levels of sperm DNA damage and oxidative stress (OS) in infertile
men with varicocele. DESIGN: Prospective controlled study. SETTING: Male infertility clinic …

An update on clinical and surgical interventions to reduce sperm DNA fragmentation in infertile men

SC Esteves, D Santi, M Simoni - Andrology, 2020 - Wiley Online Library
Background Sperm chromatin integrity is essential for normal embryo development and
pregnancy outcome. Sperm DNA fragmentation (SDF) testing constitutes a diagnostic tool to …