Unraveling the impact of nitric oxide, almitrine, and their combination in COVID-19 (at the edge of sepsis) patients: a systematic review
Y Wang, Q Yu, Y Tian, S Ren, L Liu, C Wei… - Frontiers in …, 2024 - frontiersin.org
Introduction: During the coronavirus disease 2019 (COVID-19) pandemic, a large number of
critically ill and severe COVID-19 patients meet the diagnostic criteria for sepsis and even …
critically ill and severe COVID-19 patients meet the diagnostic criteria for sepsis and even …
Impact of low dose inhaled nitric oxide treatment in spontaneously breathing and intubated COVID-19 patients: a retrospective propensity-matched study
Abstract Background The benefit of Inhaled nitric oxide (iNO) therapy in the setting of COVID-
19-related ARDS is obscure. We performed a multicenter retrospective study to evaluate the …
19-related ARDS is obscure. We performed a multicenter retrospective study to evaluate the …
A safety evaluation of intermittent high-dose inhaled nitric oxide in viral pneumonia due to COVID-19: a randomised clinical study
T Wolak, D Dicker, Y Shifer, A Grossman, A Rokach… - Scientific Reports, 2024 - nature.com
Abstract High-dose inhaled Nitric Oxide (iNO) has been shown to have anti-inflammatory,
vasodilator, and antimicrobial properties, resulting in improved arterial oxygenation as well …
vasodilator, and antimicrobial properties, resulting in improved arterial oxygenation as well …
Imaging the pulmonary vasculature in acute respiratory distress syndrome
Acute respiratory distress syndrome (ARDS) is characterized by a redistribution of regional
lung perfusion that impairs gas exchange. While speculative, experimental evidence …
lung perfusion that impairs gas exchange. While speculative, experimental evidence …
Differences in the Response to High-Dose Inhaled Nitric Oxide in Self-identified Black and White Individuals: A Post Hoc Analysis of the NOSARSCOVID Randomized …
Methods The protocol of the NOSARSCOVID trial has been described previously (6). Briefly,
the NOSARSCOVID trial was a multicenter, single-blind, randomized controlled trial …
the NOSARSCOVID trial was a multicenter, single-blind, randomized controlled trial …
Impact of airway closure and lung collapse on inhaled nitric oxide effect in acute lung injury: an experimental study
M Pellegrini, MLA Sousa, S Dubo, LS Menga… - Annals of Intensive …, 2024 - Springer
Background Efficacy of inhaled therapy such as Nitric Oxide (iNO) during mechanical
ventilation may depend on airway patency. We hypothesized that airway closure and lung …
ventilation may depend on airway patency. We hypothesized that airway closure and lung …
[HTML][HTML] Novel nitric oxide donors are coronary vasodilators that also bind to the papain-like protease of SARS-CoV-2
JF Schmedtje Jr, F Ciske, KM Muzzarelli… - Biomedicine & …, 2024 - Elsevier
Several investigational nitric oxide donors were originally created to correct vascular
endothelial dysfunction in cardiovascular diseases. These 48 compounds contain an urea …
endothelial dysfunction in cardiovascular diseases. These 48 compounds contain an urea …
Cross-sectional evaluation of medical reversals among National Institute of Health guideline practices implemented during the COVID-19 pandemic: how often did …
Objective The COVID-19 pandemic required the rapid and often widespread implementation
of medical practices without robust data. Many of these practices have since been tested in …
of medical practices without robust data. Many of these practices have since been tested in …
Immunometabolic Effect of Nitric Oxide on Human Macrophages Challenged With the SARS‐CoV2‐Induced Cytokine Storm. A Fluxomic Approach
S Sánchez‐García, A Povo‐Retana… - Advanced …, 2024 - Wiley Online Library
The cytokine storm associated with SARS‐CoV‐2 infection is one of the most distinctive
pathological signatures in COVID‐19 patients. Macrophages respond to this pro …
pathological signatures in COVID‐19 patients. Macrophages respond to this pro …
Assessment of continuous low-dose and high-dose burst of inhaled nitric oxide in spontaneously breathing COVID-19 patients: A randomized controlled trial
NO Kamenshchikov, BS Fakhr, IV Kravchenko, AY Dish… - Nitric Oxide, 2024 - Elsevier
Background Inhaled nitric oxide (iNO) showed to improve oxygenation at low doses by
reducing intrapulmonary shunt and to display antiviral properties at high doses. To assess …
reducing intrapulmonary shunt and to display antiviral properties at high doses. To assess …