Loss of muscle proteins is a deleterious consequence of chronic kidney disease (CKD) that
causes a decrease in muscle strength and function, and can lead to a reduction in quality of …

The members of the transforming growth factor β (TGF-β) superfamily are essential
regulators of cell differentiation, phenotype and function, and have been implicated in the …

Although systemic diseases take the biggest toll on human health and well-being,
increasingly, a failing brain is the arbiter of a death preceded by a gradual loss of the …

Myostatin (MSTN), a member of the transforming growth factor-β superfamily, can negatively
regulate the growth and development of skeletal muscle by autocrine or paracrine signaling …

Alzheimer's disease (AD) represents an urgent public health mandate. AD is no longer
considered a neural-centric disease; rather, a plethora of recent studies strongly implicate a …

In the last decade, clear evidence has emerged that the cellular components of skeletal
muscle are important sites for the release of proteins and peptides called “myokines” …

Novel proteomics platforms, such as the aptamer‐based SOMAscan platform, can quantify
large numbers of proteins efficiently and cost‐effectively and are rapidly growing in …

In mammals, recent studies have demonstrated that the brain, the hypothalamus in
particular, is a key bidirectional integrator of humoral and neural information from peripheral …

Growth and differentiation factor 11 (GDF11) is a transforming growth factor β superfamily
member with a controversial role in aging processes. We have developed a highly specific …

Plasma biomarkers that reflect molecular states of the cardiovascular system are central for
clinical decision making. Routinely used plasma biomarkers include troponins, natriuretic …