Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

Alzheimer's disease (AD), a common neurodegenerative disease in the elderly and the most
prevalent cause of dementia, is characterized by progressive cognitive impairment. The …

Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …

Alzheimer's disease (AD) is characterized by memory loss, cognitive decline, and
devastating neurodegeneration, not only as a result of the extracellular accumulation of beta …

Synaptic dysfunction occurs early in senile dementias, presumably as a result of decreased
levels of functional synaptic proteins as found in autopsied brains of patients with …

P38 mitogen-activated protein kinase (MAPK) is a crucial target for chronic inflammatory
diseases. Alzheimer's disease (AD) is characterized by the presence of amyloid plaques …

Tau is a protein that is highly enriched in neurons and was originally defined by its ability to
bind and stabilize microtubules. However, it is now becoming evident that the functions of …

Synaptic dysfunction is closely related to Alzheimer's disease (AD) which is also recognized
as synaptic disorder. β-amyloid (Aβ) is one of the main pathogenic factors in AD, which …

There is considerable interest in the pathobiology of tau protein, given its potential role in
neurodegenerative diseases and aging. Tau is an important microtubule associated protein …

Posttranslational modifications of proteins are important regulatory processes endowing the
proteins functional complexity. Over the last decade, numerous studies have shed light on …