Giant Cell tumors (GCT) are benign tumors with potential for aggressive behavior and
capacity to metastasize. Although rarely lethal, benign bone tumors may be associated with …

Giant cell tumor (GCT) of bone is a benign but locally aggressive tumor that usually involves
the end of long bone. Its histogenesis remains unclear. It is characterized by a proliferation …

Purpose: Giant-cell tumor of bone (GCTB) is a locally aggressive, benign osteolytic tumor in
which bone destruction is mediated by RANK ligand (RANKL). The RANKL inhibitor …

The giant cell tumour of bone (GCT) is a locally aggressive intraosseous neoplasm of
obscure biological behaviour. Although well defined in clinical, radiological and histological …

Abstract Glycine 34-to-tryptophan (G34W) substitutions in H3. 3 arise in approximately 90%
of giant cell tumor of bone (GCT). Here, we show H3. 3 G34W is necessary for tumor …

Endometrial regeneration is mediated, at least in part, by the existence of a specialized
somatic stem cell (SSC) population recently identified by several groups using the side …

During reproductive life, the human endometrium undergoes around 480 cycles of growth,
breakdown and regeneration should pregnancy not be achieved. This outstanding …

Comprehending the pathogenesis of giant cell tumor of bone (GCT) is of critical importance
for developing novel targeted treatments for this locally-aggressive primary bone tumor. GCT …

The last decade has seen the majority of primary bone tumor subtypes become defined by
molecular genetic alteration. Examples include giant cell tumour of bone (H3F3A p. G34W) …

BACKGROUND:: Giant cell tumor (GCT) of bone is a benign but locally aggressive tumor
that is characterized by the presence of mononuclear stromal cells and multinucleated giant …