Thiazole-containing compounds as therapeutic targets for cancer therapy
In the last few decades, considerable progress has been made in anticancer agents
development, and several new anticancer agents of natural and synthetic origin have been …
development, and several new anticancer agents of natural and synthetic origin have been …
Design, synthesis, and biological evaluation of new challenging thalidomide analogs as potential anticancer immunomodulatory agents
Thalidomide and its analogs are immunomodulatory drugs that inhibit the production of
certain inflammatory mediators associated with cancer. In the present work, a new series of …
certain inflammatory mediators associated with cancer. In the present work, a new series of …
Privileged structures in the design of potential drug candidates for neglected diseases
ACL Leite, JWP Espíndola… - Current Medicinal …, 2019 - ingentaconnect.com
Background: Privileged motifs are recurring in a wide range of biologically active
compounds that reach different pharmaceutical targets and pathways and could represent a …
compounds that reach different pharmaceutical targets and pathways and could represent a …
Thiazolidinone/thiazole based hybrids–New class of antitrypanosomal agents
A Kryshchyshyn, D Kaminskyy, O Karpenko… - European journal of …, 2019 - Elsevier
Different compounds have been investigated as potent drugs for trypanosomiasis treatment,
but no new drug has been marketed in the past 3 decades. 4-Thiazolidinone/thiazole as …
but no new drug has been marketed in the past 3 decades. 4-Thiazolidinone/thiazole as …
Anti-inflammatory activity of novel thiosemicarbazone compounds indole-based as COX inhibitors
ÍTT Jacob, FOS Gomes, MDS de Miranda… - Pharmacological …, 2021 - Springer
Background In this article, a series of 20 new thiosemicarbazone derivatives containing
indole were synthesized and evaluated for their anti-inflammatory potential. Methods The …
indole were synthesized and evaluated for their anti-inflammatory potential. Methods The …
Novel phthalimide based analogues: Design, synthesis, biological evaluation, and molecular docking studies
IMM Othman, MAM Gad-Elkareem… - Journal of enzyme …, 2019 - Taylor & Francis
Pyrazolylphthalimide derivative 4 was synthesized and reacted with different reagents to
afford the target compounds imidazopyrazoles 5-7, pyrazolopyrimidines 9, 12, 14 and …
afford the target compounds imidazopyrazoles 5-7, pyrazolopyrimidines 9, 12, 14 and …
Effect of the dichloro-substitution on antiproliferative activity of phthalimide-thiazole derivatives. Rational design, synthesis, elastase, caspase 3/7, and EGFR tyrosine …
B Donarska, M Świtalska, W Płaziński, J Wietrzyk… - Bioorganic …, 2021 - Elsevier
Phthalimide derivatives are a promising group of anticancer drugs, while aminothiazoles
have great potential as elastase inhibitors. In these context fourteen phthalimido-thiazoles …
have great potential as elastase inhibitors. In these context fourteen phthalimido-thiazoles …
Desing and synthesis of potent anti-Trypanosoma cruzi agents new thiazoles derivatives which induce apoptotic parasite death
EB da Silva, DAO e Silva, AR Oliveira… - European journal of …, 2017 - Elsevier
Chagas disease, caused by the kinetoplastid protozoan parasite Trypanosoma cruzi,
remains a relevant cause of illness and premature death and it is estimated that 6 million to …
remains a relevant cause of illness and premature death and it is estimated that 6 million to …
Phthalimido-thiazoles as building blocks and their effects on the growth and morphology of Trypanosoma cruzi
PAT de Moraes Gomes, AR Oliveira… - European journal of …, 2016 - Elsevier
Chagas disease is a parasitic infection caused by protozoan Trypanosoma cruzi that affects
approximately 6–7 million people worldwide. Benznidazole is the only drug approved for …
approximately 6–7 million people worldwide. Benznidazole is the only drug approved for …
Advances in synthesis and medicinal applications of compounds derived from phthalimide
ML Almeida, MCVA Oliveira, IR Pitta… - Current Organic …, 2020 - ingentaconnect.com
Phthalimide derivatives have been presenting several promising biological activities in the
literature, such as anti-inflammatory, analgesic, antitumor, antimicrobial and anticonvulsant …
literature, such as anti-inflammatory, analgesic, antitumor, antimicrobial and anticonvulsant …