In the last few decades, considerable progress has been made in anticancer agents
development, and several new anticancer agents of natural and synthetic origin have been …

Thalidomide and its analogs are immunomodulatory drugs that inhibit the production of
certain inflammatory mediators associated with cancer. In the present work, a new series of …

Background: Privileged motifs are recurring in a wide range of biologically active
compounds that reach different pharmaceutical targets and pathways and could represent a …

Different compounds have been investigated as potent drugs for trypanosomiasis treatment,
but no new drug has been marketed in the past 3 decades. 4-Thiazolidinone/thiazole as …

Background In this article, a series of 20 new thiosemicarbazone derivatives containing
indole were synthesized and evaluated for their anti-inflammatory potential. Methods The …

Pyrazolylphthalimide derivative 4 was synthesized and reacted with different reagents to
afford the target compounds imidazopyrazoles 5-7, pyrazolopyrimidines 9, 12, 14 and …

Phthalimide derivatives are a promising group of anticancer drugs, while aminothiazoles
have great potential as elastase inhibitors. In these context fourteen phthalimido-thiazoles …

Chagas disease, caused by the kinetoplastid protozoan parasite Trypanosoma cruzi,
remains a relevant cause of illness and premature death and it is estimated that 6 million to …

Chagas disease is a parasitic infection caused by protozoan Trypanosoma cruzi that affects
approximately 6–7 million people worldwide. Benznidazole is the only drug approved for …

Phthalimide derivatives have been presenting several promising biological activities in the
literature, such as anti-inflammatory, analgesic, antitumor, antimicrobial and anticonvulsant …