Multifunctional TRPV1 ion channels in physiology and pathology with focus on the brain, vasculature, and some visceral systems
MV Storozhuk, OF Moroz… - BioMed research …, 2019 - Wiley Online Library
TRPV1 has been originally cloned as the heat and capsaicin receptor implicated in acute
pain signalling, while further research has shifted the focus to its importance in chronic pain …
pain signalling, while further research has shifted the focus to its importance in chronic pain …
Cannabidiol as a potential new type of an antipsychotic. A critical review of the evidence
C Rohleder, JK Müller, B Lange… - Frontiers in …, 2016 - frontiersin.org
There is urgent need for the development of mechanistically different and less side-effect
prone antipsychotic compounds. The endocannabinoid system has been suggested to …
prone antipsychotic compounds. The endocannabinoid system has been suggested to …
Capsaicin and its effect on exercise performance, fatigue and inflammation after exercise
Capsaicin (CAP) activates the transient receptor potential vanilloid 1 (TRPV1) channel on
sensory neurons, improving ATP production, vascular function, fatigue resistance, and thus …
sensory neurons, improving ATP production, vascular function, fatigue resistance, and thus …
Role of the endocannabinoid system in the pathophysiology of schizophrenia
M Fakhoury - Molecular neurobiology, 2017 - Springer
The endocannabinoid system (ECS) is a group of neuromodulatory lipids, enzymes, and
receptors involved in numerous behavioral and physiological processes such as mood …
receptors involved in numerous behavioral and physiological processes such as mood …
Cannabidiol prevents motor and cognitive impairments induced by reserpine in rats
FF Peres, R Levin, MA Suiama, MC Diana… - Frontiers in …, 2016 - frontiersin.org
Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa that presents
antipsychotic, anxiolytic, anti-inflammatory, and neuroprotective effects. In Parkinson's …
antipsychotic, anxiolytic, anti-inflammatory, and neuroprotective effects. In Parkinson's …
Endocannabinoid system alterations in Alzheimer's disease: A systematic review of human studies
Studies investigating alterations of the endocannabinoid system (ECS) in Alzheimer's
disease (AD) in humans have reported inconsistent findings so far. We performed a …
disease (AD) in humans have reported inconsistent findings so far. We performed a …
Cannabidiol administered during peri-adolescence prevents behavioral abnormalities in an animal model of schizophrenia
FF Peres, MC Diana, R Levin, MA Suiama… - Frontiers in …, 2018 - frontiersin.org
Schizophrenia is considered a debilitating neurodevelopmental psychiatric disorder and its
pharmacotherapy remains problematic without recent major advances. The development of …
pharmacotherapy remains problematic without recent major advances. The development of …
Endocannabinoids and mental disorders
TI Rubino, E Zamberletti, D Parolaro - Endocannabinoids, 2015 - Springer
Preclinical and clinical data fully support the involvement of the endocannabinoid system in
the etiopathogenesis of several mental diseases. In this review we will briefly summarize the …
the etiopathogenesis of several mental diseases. In this review we will briefly summarize the …
Is cannabidiol during neurodevelopment a promising therapy for schizophrenia and autism spectrum disorders?
CM Loss, L Teodoro, GD Rodrigues… - Frontiers in …, 2021 - frontiersin.org
Schizophrenia and autism spectrum disorders (ASD) are psychiatric neurodevelopmental
disorders that cause high levels of functional disabilities. Also, the currently available …
disorders that cause high levels of functional disabilities. Also, the currently available …
Therapeutic potential of pharmacological agents targeting TRP channels in CNS disorders
Central nervous system (CNS) disorders like Alzheimer's disease (AD), Parkinson disease
(PD), stroke, epilepsy, depression, and bipolar disorder have a high impact on both medical …
(PD), stroke, epilepsy, depression, and bipolar disorder have a high impact on both medical …