TRPV1 has been originally cloned as the heat and capsaicin receptor implicated in acute
pain signalling, while further research has shifted the focus to its importance in chronic pain …

There is urgent need for the development of mechanistically different and less side-effect
prone antipsychotic compounds. The endocannabinoid system has been suggested to …

Capsaicin (CAP) activates the transient receptor potential vanilloid 1 (TRPV1) channel on
sensory neurons, improving ATP production, vascular function, fatigue resistance, and thus …

The endocannabinoid system (ECS) is a group of neuromodulatory lipids, enzymes, and
receptors involved in numerous behavioral and physiological processes such as mood …

Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa that presents
antipsychotic, anxiolytic, anti-inflammatory, and neuroprotective effects. In Parkinson's …

Studies investigating alterations of the endocannabinoid system (ECS) in Alzheimer's
disease (AD) in humans have reported inconsistent findings so far. We performed a …

Schizophrenia is considered a debilitating neurodevelopmental psychiatric disorder and its
pharmacotherapy remains problematic without recent major advances. The development of …

Preclinical and clinical data fully support the involvement of the endocannabinoid system in
the etiopathogenesis of several mental diseases. In this review we will briefly summarize the …

Schizophrenia and autism spectrum disorders (ASD) are psychiatric neurodevelopmental
disorders that cause high levels of functional disabilities. Also, the currently available …

Central nervous system (CNS) disorders like Alzheimer's disease (AD), Parkinson disease
(PD), stroke, epilepsy, depression, and bipolar disorder have a high impact on both medical …