Host immune responses to salivary components-a critical facet of tick-host interactions

A Ali, I Zeb, A Alouffi, H Zahid, MM Almutairi… - Frontiers in Cellular …, 2022 - frontiersin.org
Tick sialome is comprised of a rich cocktail of bioactive molecules that function as a tool to
disarm host immunity, assist blood-feeding, and play a vibrant role in pathogen …

Tick attachment cement–reviewing the mysteries of a biological skin plug system

J Suppan, B Engel, M Marchetti‐Deschmann… - Biological …, 2018 - Wiley Online Library
The majority of ticks in the family Ixodidae secrete a substance anchoring their mouthparts to
the host skin. This substance is termed cement. It has adhesive properties and seals the …

A US isolate of Theileria orientalis, Ikeda genotype, is transmitted to cattle by the invasive Asian longhorned tick, Haemaphysalis longicornis

KD Dinkel, DR Herndon, SM Noh, KK Lahmers… - Parasites & vectors, 2021 - Springer
Background Theileria orientalis is a tick-borne hemoparasite that causes anemia, ill thrift,
and death in cattle globally. The Ikeda strain of T. orientalis is more virulent than other …

Ixodes scapularis Tick Saliva Proteins Sequentially Secreted Every 24 h during Blood Feeding

TK Kim, L Tirloni, AFM Pinto, J Moresco… - PLoS neglected …, 2016 - journals.plos.org
Ixodes scapularis is the most medically important tick species and transmits five of the 14
reportable human tick borne disease (TBD) agents in the USA. This study describes LC …

Molecular Detection of Tick-Borne Bacterial and Protozoan Pathogens in Haemaphysalis longicornis (Acari: Ixodidae) Ticks from Free-Ranging Domestic Sheep in …

Z Teng, Y Shi, N Zhao, X Zhang, X Jin, J He, B Xu… - Pathogens, 2023 - mdpi.com
Ticks and tick-borne pathogens significantly threaten human and animal health worldwide.
Haemaphysalis longicornis is one of the dominant tick species in East Asia, including China …

The use of tick salivary proteins as novel therapeutics

J Chmelař, J Kotál, A Kovaříková… - Frontiers in physiology, 2019 - frontiersin.org
The last three decades of research into tick salivary components have revealed several
proteins with important pharmacological and immunological activities. Two primary interests …

Serine protease inhibitors in ticks: an overview of their role in tick biology and tick-borne pathogen transmission

AA Blisnick, T Foulon, SI Bonnet - Frontiers in Cellular and Infection …, 2017 - frontiersin.org
New tick and tick-borne pathogen control approaches that are both environmentally
sustainable and which provide broad protection are urgently needed. Their development …

Tick innate immune responses to hematophagy and Ehrlichia infection at single-cell resolution

A Adegoke, JMC Ribeiro, RC Smith… - Frontiers in …, 2024 - frontiersin.org
Introduction Ticks rely on robust cellular and humoral responses to control microbial
infection. However, several aspects of the tick's innate immune system remain …

Ixodes scapularis nymph saliva protein blocks host inflammation and complement-mediated killing of Lyme disease agent, Borrelia burgdorferi

E Bencosme-Cuevas, TK Kim, TT Nguyen… - Frontiers in Cellular …, 2023 - frontiersin.org
Tick serine protease inhibitors (serpins) play crucial roles in tick feeding and pathogen
transmission. We demonstrate that Ixodes scapularis (Ixs) nymph tick saliva serpin (S) 41 …

Secretome Analysis and In Planta Expression of Salivary Proteins Identify Candidate Effectors from the Brown Planthopper Nilaparvata lugens

W Rao, X Zheng, B Liu, Q Guo, J Guo… - Molecular Plant …, 2019 - Am Phytopath Society
The brown planthopper (BPH), Nilaparvata lugens (Stål), is a phloem sap-feeding insect.
During feeding on rice plants, BPH secretes salivary proteins with potential effector …