Chemistry of MRI contrast agents: current challenges and new frontiers

J Wahsner, EM Gale, A Rodríguez-Rodríguez… - Chemical …, 2018 - ACS Publications
Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are
performed annually around the world. The contrast agents, which improve diagnostic …

Ferritin nanocage: A promising and designable multi-module platform for constructing dynamic nanoassembly-based drug nanocarrier

B Zhang, G Tang, J He, X Yan, K Fan - Advanced Drug Delivery Reviews, 2021 - Elsevier
Ferritin has been widely recognized as an ideal drug delivery vehicle owing to its unique
cage-like structure. Coupled with intrinsic targeting ability and excellent biosafety, ferritin …

Overexpression of the MRI reporter genes ferritin and transferrin receptor affect iron homeostasis and produce limited contrast in mesenchymal stem cells

SM Pereira, D Moss, SR Williams, P Murray… - International Journal of …, 2015 - mdpi.com
Imaging technologies that allow the non-invasive monitoring of stem cells in vivo play a vital
role in cell-based regenerative therapies. Recently, much interest has been generated in …

MRI reporter genes for noninvasive molecular imaging

C Yang, R Tian, T Liu, G Liu - Molecules, 2016 - mdpi.com
Magnetic resonance imaging (MRI) is one of the most important imaging technologies used
in clinical diagnosis. Reporter genes for MRI can be applied to accurately track the delivery …

[HTML][HTML] Longitudinal monitoring of stem cell grafts in vivo using magnetic resonance imaging with inducible maga as a genetic reporter

IK Cho, SP Moran, R Paudyal, K Piotrowska-Nitsche… - Theranostics, 2014 - ncbi.nlm.nih.gov
Purpose: The ability to longitudinally monitor cell grafts and assess their condition is critical
for the clinical translation of stem cell therapy in regenerative medicine. Developing an …

Genetic manipulation of iron biomineralization enhances MR relaxivity in a ferritin-M6A chimeric complex

M Radoul, L Lewin, B Cohen, R Oren, S Popov… - Scientific reports, 2016 - nature.com
Ferritin has gained significant attention as a potential reporter gene for in vivo imaging by
magnetic resonance imaging (MRI). However, due to the ferritin ferrihydrite core, the …

Engineered ferritin nanocages as natural contrast agents in magnetic resonance imaging

V Nandwana, SR Ryoo, S Kanthala, A Kumar… - RSC …, 2017 - pubs.rsc.org
We report the development of a self-assembling protein nanocage as a contrast agent for
magnetic resonance imaging (MRI). The protein nanocage is derived from genetically …

Genetically controlled lysosomal entrapment of superparamagnetic ferritin for multimodal and multiscale imaging and actuation with low tissue attenuation

C Massner, F Sigmund, S Pettinger… - Advanced Functional …, 2018 - Wiley Online Library
Nanomaterials are of enormous value for biomedical applications because of their
customizable features. However, the material properties of nanomaterials can be altered …

Paramagnetic colloidal ferrihydrite nanoparticles for MRI contrasting

IL Sokolov, VR Cherkasov, AV Vasilyeva… - Colloids and Surfaces A …, 2018 - Elsevier
MRI-contrasting agents based on paramagnetic molecules and superparamagnetic
nanoparticles substantially enhance the resolution and stimulate developments of new …

Reporter gene approaches for mapping cell fate decisions by MRI: promises and pitfalls

GV Velde, U Himmelreich… - Contrast Media & …, 2013 - Wiley Online Library
The central dogma of molecular biology, namely the process by which information encoded
in the DNA serves as the template for transcriptional activation of specific mRNA resulting in …