Biomimetic natural biomaterials for tissue engineering and regenerative medicine: new biosynthesis methods, recent advances, and emerging applications

S Liu, JM Yu, YC Gan, XZ Qiu, ZC Gao, H Wang… - Military Medical …, 2023 - Springer
Biomimetic materials have emerged as attractive and competitive alternatives for tissue
engineering (TE) and regenerative medicine. In contrast to conventional biomaterials or …

Uncovering the structure–function relationship in spider silk

JL Yarger, BR Cherry, A Van Der Vaart - Nature Reviews Materials, 2018 - nature.com
All spiders produce protein-based biopolymer fibres that we call silk. The most studied of
these silks is spider dragline silk, which is very tough and relatively abundant compared with …

1000 spider silkomes: Linking sequences to silk physical properties

K Arakawa, N Kono, AD Malay, A Tateishi, N Ifuku… - Science …, 2022 - science.org
Spider silks are among the toughest known materials and thus provide models for
renewable, biodegradable, and sustainable biopolymers. However, the entirety of their …

Protein secondary structure in spider silk nanofibrils

Q Wang, P McArdle, SL Wang, RL Wilmington… - Nature …, 2022 - nature.com
Nanofibrils play a pivotal role in spider silk and are responsible for many of the impressive
properties of this unique natural material. However, little is known about the internal …

[HTML][HTML] Tuning the conformation and mechanical properties of silk fibroin hydrogels

N Johari, L Moroni, A Samadikuchaksaraei - European Polymer Journal, 2020 - Elsevier
Mechanical properties of biomaterials play an important role in their biological performance.
Among the most important parameters in designing of biomaterials, their structure and …

Spider silk fibers spun from soluble recombinant silk produced in mammalian cells

A Lazaris, S Arcidiacono, Y Huang, JF Zhou, F Duguay… - science, 2002 - science.org
Spider silks are protein-based “biopolymer” filaments or threads secreted by specialized
epithelial cells as concentrated soluble precursors of highly repetitive primary sequences …

Multicomponent nature underlies the extraordinary mechanical properties of spider dragline silk

N Kono, H Nakamura, M Mori… - Proceedings of the …, 2021 - National Acad Sciences
Dragline silk of golden orb-weaver spiders (Nephilinae) is noted for its unsurpassed
toughness, combining extraordinary extensibility and tensile strength, suggesting industrial …

The molecular structure of spider dragline silk: folding and orientation of the protein backbone

JD Van Beek, S Hess, F Vollrath… - Proceedings of the …, 2002 - National Acad Sciences
The design principles of spider dragline silk, nature's high-performance fiber, are still largely
unknown, in particular for the noncrystalline glycine-rich domains, which form the bulk of the …

Composite materials based on silk proteins

JG Hardy, TR Scheibel - Progress in Polymer Science, 2010 - Elsevier
A number of animals have evolved to produce silk-based composite materials for a variety of
task-specific applications. The review initially focuses on the composite structure of silk …

Protein secondary structure and orientation in silk as revealed by Raman spectromicroscopy

T Lefèvre, ME Rousseau, M Pézolet - Biophysical journal, 2007 - cell.com
Taking advantage of recent advances in polarized Raman microspectroscopy, and based on
a rational decomposition of the amide I band, the conformation and orientation of proteins …