Herpes simplex virus type 1 (HSV-1) is a structurally complex enveloped dsDNA virus that
has evolved to replicate in human neurons and epithelia. Viral gene expression, DNA …

In the last year the COVID19 pandemic clearly illustrated the potential threat that viruses
pose to our society. The characterization of viral structures and the identification of key …

Neurotropic alphaherpesviruses initiate infection in exposed mucosal tissues and, unlike
most viruses, spread rapidly to sensory and autonomic nerves where life-long latency is …

Background Pseudorabies virus (PRV) infections in susceptible non-porcine species trigger
uncontrolled inflammations and eventually fatal encephalitis. Resveratrol (Res) has broad …

Alpha herpesviruses naturally infect the peripheral nervous system, and can spread to the
central nervous system, causing severe debilitating or deadly disease. Because alpha …

During infection of neurons by alphaherpesviruses including Pseudorabies virus (PRV) and
Herpes simplex virus type 1 (HSV-1) viral nucleocapsids assemble in the cell nucleus …

The literature on the egress of different herpesviruses after secondary envelopment is
contradictory. In this report, we investigated varicella-zoster virus (VZV) egress in a cell line …

Membrane trafficking is an essential cellular process conserved across all eukaryotes, which
regulates the uptake or release of macromolecules from cells, the composition of cellular …

Herpes simplex virus type 1 (HSV-1) has evolved mechanisms to exploit the host
cytoskeleton during entry, replication and exit from cells. In this study, we determined the …

The cerebral arteries are innervated by afferent fibers from the trigeminal ganglia. Varicella-
zoster virus (VZV) frequently resides in the trigeminal ganglion. Reports of arterial ischemic …