Coiled coils–a model system for the 21st century
α-Helical coiled coils were described more than 60 years ago as simple, repetitive structures
mediating oligomerization and mechanical stability. Over the past 20 years, however, they …
mediating oligomerization and mechanical stability. Over the past 20 years, however, they …
Type V secretion: mechanism (s) of autotransport through the bacterial outer membrane
Autotransport in Gram-negative bacteria denotes the ability of surface-localized proteins to
cross the outer membrane (OM) autonomously. Autotransporters perform this task with the …
cross the outer membrane (OM) autonomously. Autotransporters perform this task with the …
Adhesive Mechanisms of Salmonella enterica
C Wagner, M Hensel - Bacterial Adhesion: Chemistry, Biology and Physics, 2011 - Springer
Salmonella enterica is an invasive, facultative intracellular pathogen of animal and man with
the ability to colonize various niches in diverse host organisms. The pathogenesis of …
the ability to colonize various niches in diverse host organisms. The pathogenesis of …
Type V secretion systems in bacteria
E Fan, N Chauhan, DG Udatha… - … of Bacterial Pathogens, 2016 - Wiley Online Library
Gram‐negative bacteria are surrounded by two membranes, called the outer and inner
membranes. The space between these membranes, the periplasm, is spanned by a …
membranes. The space between these membranes, the periplasm, is spanned by a …
Designing Multivalent and Multispecific Biologics
JJ Kang, A Ohoka, CA Sarkar - Annual Review of Chemical and …, 2023 - annualreviews.org
In the era of precision medicine, multivalent and multispecific therapeutics present a
promising approach for targeted disease intervention. These therapeutics are designed to …
promising approach for targeted disease intervention. These therapeutics are designed to …
SadA, a trimeric autotransporter from Salmonella enterica serovar Typhimurium, can promote biofilm formation and provides limited protection against infection
Salmonella enterica is a major cause of morbidity worldwide and mortality in children and
immunocompromised individuals in sub-Saharan Africa. Outer membrane proteins of …
immunocompromised individuals in sub-Saharan Africa. Outer membrane proteins of …
A coiled-coil motif that sequesters ions to the hydrophobic core
MD Hartmann, O Ridderbusch, K Zeth… - Proceedings of the …, 2009 - National Acad Sciences
Most core residues of coiled coils are hydrophobic. Occasional polar residues are thought to
lower stability, but impart structural specificity. The coiled coils of trimeric autotransporter …
lower stability, but impart structural specificity. The coiled coils of trimeric autotransporter …
[HTML][HTML] Structure of the Head of the Bartonella Adhesin BadA
P Szczesny, D Linke, A Ursinus, K Bär… - PLoS …, 2008 - journals.plos.org
Trimeric autotransporter adhesins (TAAs) are a major class of proteins by which pathogenic
proteobacteria adhere to their hosts. Prominent examples include Yersinia YadA …
proteobacteria adhere to their hosts. Prominent examples include Yersinia YadA …
[HTML][HTML] A domain dictionary of trimeric autotransporter adhesins
Trimeric autotransporter adhesins (TAAs) are modular, highly repetitive outer membrane
proteins that mediate adhesion to external surfaces in many Gram-negative bacteria. In …
proteins that mediate adhesion to external surfaces in many Gram-negative bacteria. In …
[HTML][HTML] Improved expression of secretory and trimeric proteins in mammalian cells via the introduction of a new trimer motif and a mutant of the tPA signal sequence
JY Wang, WT Song, Y Li, WJ Chen, D Yang… - Applied microbiology …, 2011 - Springer
Ideal immunogenicity in antigens is a prerequisite to eliciting a sufficiently strong immune
and memory response via either DNA or protein vaccines. To improve immunogenicity …
and memory response via either DNA or protein vaccines. To improve immunogenicity …