The necessity for the discovery of innovative antimicrobials to treat life-threatening diseases
has increased as multidrug-resistant bacteria has spread. Due to antibiotics' availability over …

The development of structure-guided drug discovery is a story of knowledge exchange
where new ideas originate from all parts of the research ecosystem. Dorothy Crowfoot …

Reactive oxygen species (ROS)-mediated oxidative stress and DNA damage have recently
been recognized as contributing to the efficacy of most bactericidal antibiotics, irrespective of …

Tuberculosis (TB) remains a major cause of mortality worldwide, and improved treatments
are needed to combat emergence of drug resistance. Inosine 5′-monophosphate …

Structure-guided drug discovery emerged in the 1970s and 1980s, stimulated by the three-
dimensional structures of protein targets that became available, mainly through X-ray crystal …

Tuberculosis (TB) remains a leading cause of mortality among infectious diseases
worldwide. InhA has been the focus of numerous drug discovery efforts as this is the target of …

Mycobacterium abscessus (Mab) has emerged as a challenging threat to individuals with
cystic fibrosis. Infections caused by this pathogen are often impossible to treat due to the …

The L-arginine biosynthesis pathway consists of eight enzymes that catalyse the conversion
of L-glutamate to L-arginine. Arginine auxotrophs (argB/argF deletion mutants) of …

Of the more than 190 distinct species of Mycobacterium genus, many are economically and
clinically important pathogens of humans or animals. Among those mycobacteria that infect …

While target-based drug design has proved successful in several therapeutic areas, this
approach has not yet provided compelling outcomes in the field of antibacterial agents. This …