Vulvodynia

S Bergeron, BD Reed, U Wesselmann… - Nature reviews disease …, 2020 - nature.com
Vulvodynia is a condition that occurs in 8–10% of women of all ages and is characterized by
pain at the vulva that is present during sexual and/or non-sexual situations. Diagnosis is …

[HTML][HTML] Vulvodynia—it is time to accept a new understanding from a neurobiological perspective

R Torres-Cueco, F Nohales-Alfonso - International Journal of …, 2021 - mdpi.com
Vulvodynia is one the most common causes of pain during sexual intercourse in
premenopausal women. The burden of vulvodynia in a woman's life can be devastating due …

Anti-inflammatory effects of androgens in the human vagina

E Maseroli, I Cellai, S Filippi… - Journal of …, 2020 - jme.bioscientifica.com
Chronic inflammation is involved in the genitourinary syndrome of menopause (GSM) and
beneficial effects of androgens in the vagina have been described. We investigated the …

Inflammation, lipids, and pain in vulvar disease

ML Falsetta, KR Maddipati, KV Honn - Pharmacology & Therapeutics, 2023 - Elsevier
Localized provoked vulvodynia (LPV) affects∼ 14 million people in the US (9% of women),
destroying lives and relationships. LPV is characterized by chronic pain (> 3 months) upon …

[HTML][HTML] Inflammation, lipid dysregulation, and transient receptor potential cation channel subfamily V member 4 signaling perpetuate chronic vulvar pain

T Bekauri, S Fischer, KV Honn, KR Maddipati, T Love… - Pain, 2024 - journals.lww.com
Localized provoked vulvodynia is characterized by chronic vulvar pain that disrupts every
aspect of the patient's life. Pain is localized to the vulvar vestibule, a specialized ring of …

[HTML][HTML] Specialized pro-resolving mediators reduce pro-nociceptive inflammatory mediator production in models of localized provoked vulvodynia

ML Falsetta, RW Wood, MA Linder, AD Bonham… - The journal of pain, 2021 - Elsevier
Localized provoked vulvodynia (LPV) is the most common cause of chronic dyspareunia in
premenopausal women, characterized by pain with light touch to the vulvar vestibule …

[HTML][HTML] Emerging evidence of macrophage contribution to hyperinnervation and nociceptor sensitization in vulvodynia

CM Barry, D Matusica, RV Haberberger - Frontiers in molecular …, 2019 - frontiersin.org
Vulvodynia is an idiopathic chronic pain disorder and a leading cause of dyspareunia, or
pain associated with sexual intercourse, for women. The key pathophysiological features of …

Provoked vulvar vestibulodynia: Epidemiology in Europe, physio-pathology, consensus for first-line treatment and evaluation of second-line treatments

E Bautrant, O Porta, F Murina… - Journal of …, 2019 - pubmed.ncbi.nlm.nih.gov
Provoked vulvar vestibulodynia: Epidemiology in Europe, physio-pathology, consensus for
first-line treatment and evaluation of second-line treatments Provoked vulvar vestibulodynia …

[HTML][HTML] Dysregulated wound healing in the pathogenesis of urogynecologic mesh complications

AM Artsen, R Liang, L Meyn, MS Bradley, PA Moalli - Scientific Reports, 2023 - nature.com
To test the hypothesis that dysregulated wound healing is associated with Urogynecologic
mesh complications, we collected vaginal cell secretions using vaginal swabs after …

Vaginal microbiota and mucosal immune markers in women with vulvovaginal discomfort

CM Mitchell, LT Watson, AJ Mitchell… - Sexually transmitted …, 2020 - journals.lww.com
Background Up to 30% of women with vaginal symptoms are not assigned a diagnosis after
standard diagnostic assessment. Methods We compared premenopausal women with …