Cancer immunotherapy has made impressive advances in improving the outcome of
patients affected by malignant diseases. Nonetheless, some limitations still need to be …

Bone regeneration following trauma, tumor resection, infection, or congenital disease is
challenging. Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia …

Background: High-mobility group box 1 protein (HMGB1) was identified as a highly
conserved DNA binding nuclear protein, which participates in the processes of acute lung …

Immunotherapy targeting the PD-1/PD-L1 receptor has achieved great success in
melanoma patients. Although many studies have addressed the underlying mechanisms …

Rosmarinic acid (RA), a natural phenolic acid compound with a variety of bioactive
properties. However, the antidepressant activity and mechanism of RA remain unclear. The …

Bone defects caused by trauma, tumor resection, congenital malformation and infection are
still a major challenge for clinicians. Biomimetic bone materials have attracted more and …

Thyroid-associated ophthalmopathy (TAO) is a vexing and poorly understood autoimmune
process involving the upper face and tissues surrounding the eyes. In TAO, the orbit can …

Diabetic nephropathy (DN) is a progressive disease, the main pathogeny of which is
podocyte injury. As a calcium-dependent serine/threonine protein kinase involved in …

Rationale The recent research found that IGF regulator genes played a pivotal role in
multiple biological processes, which may be developed for cancer treatment. However, the …

Background: Epidemiological studies observed gender differences in COVID-19 outcomes,
however, whether sex hormone plays a causal in COVID-19 risk remains unclear. This study …